Inflammatory Markers and Incidence of Hospitalization with Infection in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort (CRIC) Study.

Inflammatory Markers and Incidence of Hospitalization with Infection in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Epidemiol. 2019 Nov 01;: Authors: Ishigami J, Taliercio J, Feldman H, Srivastava A, Townsend R, Cohen D, Horwitz E, Rao P, Charleston J, Fink JC, Ricardo AC, Sondheimer J, Chen TK, Wolf M, Isakova T, Appel LJ, Matsushita K, CRIC study investigators Abstract Persons with chronic kidney disease (CKD) are at high risk of infection. While low-grade inflammation may impair immune response, it is unknown whether inflammatory markers are associated with infection risk in this clinical population. Using 2003-2013 data from the Chronic Renal Insufficiency Cohort Study (3,597 participants with CKD), we assessed the association of baseline plasma levels of four inflammatory markers (interleukin-6 [IL-6], tumor necrosis factor-α [TNF-α], interleukin-1 receptor antagonist [IL-1RA], and transforming growth factor-β [TGF-β]), with incident hospitalization with major infection (pneumonia, urinary tract infection, cellulitis and osteomyelitis, and bacteremia and sepsis). During follow-up (median 7.5years), 36% (n=1,290) had incident hospitalization with major infection. In multivariable Cox analyses with each inflammatory marker modeled as a restricted cubic spline, higher levels of IL-6 and TNF-α were monotonically associated with increased risk of hospitalization with major infection (HR at 9...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research