Role of the NF- κB signaling pathway in the pathogenesis of colorectal cancer.

Role of the NF-κB signaling pathway in the pathogenesis of colorectal cancer. Gene. 2019 Oct 26;:144132 Authors: Soleimani A, Rahmani F, Ferns GA, Ryzhikov M, Avan A, Hassanian SM Abstract The NF-κB signaling pathway is a key regulator of CRC cell proliferation, apoptosis, angiogenesis, inflammation, metastasis, and drug resistance. Over-activation of the NF-κB pathway is a feature of colorectal cancer (CRC). While new combinatorial treatments have improved overall patient outcome; quality of life, cost of care, and patient survival rate have seen little improvement. Suppression of the NF-κB signaling pathway using biological or specific pharmacological inhibitors is a potential therapeutic approach in the treatment of colon cancer. This review summarizes the regulatory role of NF-κB signaling pathway in the pathogenesis of CRC for a better understanding and hence a better management of the disease. PMID: 31669643 [PubMed - as supplied by publisher]
Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research