Benign soft tissue tumors in children.

Benign soft tissue tumors in children. Orthop Clin North Am. 2013 Jul;44(3):433-44 Authors: Thacker MM Abstract Soft tissue masses in children are common, yet can pose a diagnostic dilemma for the orthopedic surgeon who is asked to evaluate them. Although most lesions are dysplastic or benign, some soft tissue sarcomas are seen in the pediatric population. An understanding of the clinical presentation and imaging findings can guide the surgeon decide on the need for a biopsy and formulate an appropriate treatment plan. PMID: 23827845 [PubMed - in process]
Source: The Orthopedic Clinics of North America - Category: Orthopaedics Authors: Tags: Orthop Clin North Am Source Type: research

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Publication date: Available online 30 May 2020Source: Journal of Clinical Orthopaedics and TraumaAuthor(s): Raja Bhaskara Rajasekaran, Duncan Whitwell, Thomas Daniel Arthur Cosker, Christopher Leonard Max Gibbons
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
Publication date: Available online 30 May 2020Source: Gynecologic Oncology ReportsAuthor(s): Shaina Sedighim, Jonathan Burke, Douglas Schneider, Talia Kamdjou, Julio A. Diaz-Perez, Jonathan Trent, Mecker Möller
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
AbstractWe herein describe soft tissue tumor arising in the lower extremity of a pediatric patient. The tumor displayed a unique and wide range of histological features, sheet-like and cohesive growth pattern consisting of enlarged round to epithelioid atypical cells with a large alveolar and pseudopapillary histological architecture, focally mimicking alveolar soft part sarcoma and MiT family translocation renal cell carcinoma. Tumor cells were focally immunoreactive for cytokeratin, S-100, and EMA. RNA sequencing identified a novel in-frameNR1D1 (exon 5)-MAML1 (exon 2) gene rearrangement resulting in the formation of a p...
Source: Virchows Archiv - Category: Pathology Source Type: research
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Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: REVIEW Source Type: research
Conclusion: Radiomic analysis showed potential in differentiating OS from EWS of the pelvis, in which T2-FS demonstrated better diagnostic value. To differentiate OS from EWS of the pelvis using our multiparametric MRI-based radiomic analysis could preoperatively improve diagnostic accuracy and greatly contribute to therapy planning. PMID: 32462033 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
AbstractFew millions of new cancer cases are diagnosed worldwide every year. Due to significant progress in understanding cancer biology and developing new therapies, the mortality rates are decreasing with many of patients that can be completely cured. However, vast majority of them require chemotherapy which comes with high medical costs in terms of adverse events, of which cardiotoxicity is one of the most serious and challenging. Anthracyclines (doxorubicin, epirubicin) are a class of cytotoxic agents used in treatment of breast cancer, sarcomas, or hematological malignancies that are associated with high risk of cardi...
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Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
(University of Texas M. D. Anderson Cancer Center) The adoptive T-cell therapy ADP-A2M4, which is engineered to express a T-cell receptor (TCR) directed against the MAGE-A4 cancer antigen, achieved responses in patients with multiple solid tumor types, including synovial sarcoma, head and neck cancer and lung cancer, according to results from a Phase I clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Follicular dendritic cell sarcoma (FDCS) is a low-grade malignant neoplasm that tends to be under-recognized owing to its rarity and wide pathologic spectrum. Knowledge of the atypical morphology and immunophenotype of FDCS is critical to avoid misdiagnosis. Here we presented a case of extranodal FDCS with an unusual morphology and a previously unreported immunophenotype leading to misdiagnosis. A 32-years-old man presented with a tonsilar mass that showed epithelioid cells in nested and alveolar patterns. Immunohistochemistry study revealed that the tumor cells were positive for CD4 and CD30, and were negative for cytoker...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
This study explores its metabolic diversity and compounds involved in its cytotoxic activity. Extracts from the extracellular fraction of strain USBA 371 showed high levels of cytotoxic activity associated with the production of diketopiperazines (DKPs). We purified two compounds and a mixture of two other compounds from this fraction. Their structures were characterized by 1D and 2D nuclear magnetic resonance (NMR). The purified compounds were evaluated for additional cytotoxic activities. Compound 1 (cyclo (l-Pro-l-Tyr)) showed cytotoxicity to the following cancer cell lines: breast cancer 4T1 (IC50 57.09 ± 2....
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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