Early life exposure to oral antibiotics and lung function into early adulthood.

Early life exposure to oral antibiotics and lung function into early adulthood. Chest. 2019 Oct 24;: Authors: Santos KD, Lodge CJ, Abramson MJ, Erbas B, Bennett CM, Hui J, Dharmage SC, Lowe AJ Abstract BACKGROUND: While there is ongoing debate about the impact of early postnatal exposure to antibiotics on the development of asthma, the possibility that antibiotic exposure may impair lung function has not previously been examined. Furthermore, it is not clear if specific types of antibiotics may have a greater effect, or if children with genetic mutations in the oxidative stress response glutathione S-transferase (GST) superfamily may be at greater risk. METHODS: We collected parent-report of childhood antibiotic use from birth to 2 years, including type and indication, from a birth-cohort of 620 infants with a family history of allergy. Spirometry was performed at 12 and 18 years and results are presented as z-scores. Participants were genotyped for GST-P, GST-M and GST-T polymorphisms. Linear regression models were used to investigate the associations, while adjusting for confounding factors. RESULTS: Neither increasing days of exposure nor earlier exposure to antibiotics was associated with reduced FEV1 (at 18 years, per doubling of days of exposure = -0.03 z-score units, 95%CI=-0.11, 0.04) or FVC (
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research

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Authors: Ring B, Burbank AJ, Mills K, Ivins S, Dieffenderfer J, Hernandez ML Abstract Objectives: Objective measurements of asthma impairment could aid teens in recognition of changes in asthma status over time. Ready access to a conventional spirometer is not realistic outside of the clinical setting. In this proof-of-concept study, we compared the performance of the VitalFlo mobile spirometer to the nSpire KoKo® sx1000 spirometer for accuracy in measuring Forced Expiratory Volume in one second (FEV1) and Forced Vital Capacity (FVC) in adolescents with asthma.Methods: Two hundred forty pulmonary function measu...
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Conclusions: Variation in the NAT1 gene modifies asthma risk in children exposed to secondhand-smoke. To our knowledge, this is the first report of a gene-environment interaction between NAT1 variants, smoke exposure, cotinine levels, and pediatric asthma. NAT1 genotype may have clinical utility as a biomarker of increased asthma risk in children exposed to smoke. PMID: 31809667 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Conclusion This study suggests that specific questions about triggers and severity of wheeze, measurement of FeNO and BPT by methacholine or exercise contribute more to the diagnosis of asthma in school-aged children than spirometry, bronchodilator reversibility and skin-prick tests.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Asthma and allergy, Paediatric pulmonology Original Articles: Asthma and paediatrics Source Type: research
Conclusions: Our study suggest the functional activity of IgE to SEs in severe asthmatic patients. These results can be clinically relevant in patients not sensitized to perennial allergens who can be candidates to anti-IgE therapy.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Introduction: In differential diagnosis of allergic diseases, such as asthma, chronic urticaria (CU) and Hymenoptera venom allergy (HVA), the complete blood count (CBC) and spirometry are one of the crucial examinations.Aims and Objectives: To assess the blood lymphocytes, monocytes, basophiles and neutrophils and spirometry parameters in patients with asthma, CU and HVA in comparison to healthy subjects.Methods: The study involved 48 patients with asthma, 19 with CU, 12 with HVA and 17 healthy individuals. Participants had a spirometry and CBC examinations performed.Results: The absolute values of neutrophils were highest...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Aim: Examination of patients (pts) with two broncho-obstructive diseases (A and COPD) requires addressing the issue: is it originally A or COPD? We looked at the problem from COPD.Material and Methods: We studied 38 smokers with COPD II-III stages (age–61.4±3.8 yrs, pack/year–28.8±4.3) repeatedly (3-8 yrs) in stable phase on adequate therapy. Measurements included clinical status, spirometry with bronchoobstructive reversibility test (BORT) and allergic markers: blood eosinophil level (E), common IgE level (cIgE) in plasma, Phadiatop (Ph) in serum. Each patient underwent from 3 to 9 (6.2±1....
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Aspergillus (ASP) sensitization is frequent in severe asthma (SA). Aspergillus-associated disease, such as allergic bronchopulmonary aspergillosis (ABPA) and chronic pulmonary aspergillosis (CPA) can be associated with bronchiectasis (B). B is a comorbidity in patients with SA. We investigated the prevalence and the characteristics of Aspergillus-associated bronchiectasis in 73 consecutive immunocompetent patients with SA.Methods: All the patients underwent assessment of history, spirometry, FENO, circulating eosinophils (EOS), serum total IgE, IgE-ASP (increased if> 0.10 kUA/L), and IgG-ASP (increased if>40 U/ml), c...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Conclusions: Despite guideline recommendations, PFT to diagnose and manage asthma remains low from 2000-2016 in Ontario. Although there are decreasing trends in hospitalizations and ED visits, it is important to promote the use of PFT to objectively diagnose and manage asthma in order to further reduce acute care and improve the health status of people with asthma.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
Conclusions: Our observations suggest detrimental effect of IFN in asthma pathogenesis.The study was supported by RFBR (#18-54-53019).
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
The association between asthma and obesity has been obeserved in many studies but the underlying mechanisms are poorly understood. Aim of the work is to evaluate the respiratory function (forced spirometry, residual volume [RV], DLCO, oscillometry [IOS] and serum concentration of IL-10, IL1-β, TGF-β1, TNF-α, IL-33, adiponectin, leptin in 28 obese non asthmatic children (O+NA) (20 M, median age: 11,7 yrs), compared with 28 obese asthmatic (O+A) and 28 non-obese asthmatic (NO+A), overlapped for sex and age, The results are the following:O+NAMedian (1-3 quartile)O+ANO+AO+NA vs O+AO+NA vs NO+Ap valueO+A vs NO+A...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric asthma and allergy Source Type: research
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