Correlation of IL-6 secretion and hyponatremia with the use of CD19+ chimeric antigen receptor T-cells 
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CONCLUSION: Hyponatremia is common in patients who received CD19+ CAR T-cells. There is an inverse linear relationship between IL-6 levels and nadir Na (p = 0.001). Further studies will be needed to confirm a causative relationship between IL-6 levels and hyponatremia following CD19+ CAR T-cell infusion.
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PMID: 31670650 [PubMed - as supplied by publisher]

Source: Clinical Nephrology - October 30, 2019 Category: Urology & Nephrology Authors: Dixon BN, Daley RJ, Buie LW, Hsu M, Park JH, Brentjens RJ, Purdon TJ, Latcha S Tags: Clin Nephrol Source Type: research