Cornel Iridoid Glycoside Improves Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion via Activating PI3K/Akt/GSK-3 β/CREB Pathway in Rats.

Cornel Iridoid Glycoside Improves Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion via Activating PI3K/Akt/GSK-3β/CREB Pathway in Rats. Behav Brain Res. 2019 Oct 24;:112319 Authors: Wang MY, Meng M, Yang CC, Zhang L, Li YL, Zhang L, Li L Abstract Chronic cerebral hypoperfusion is an important risk factor for vascular dementia (VaD) and other brain dysfunctions, for which there are currently no effective medications available. In the present study, we investigated the potential therapeutic effects of cornel iridoid glycoside (CIG) on VaD in rats modeled by permanent bilateral common carotid artery ligation (2-vessel occlusion, 2VO). The object recognition test (ORT) and Morris water maze (MWM) test were conducted to evaluate the learning and memory function. Western blot analysis and immunohistochemical staining were used to detect the expression of related proteins. Results showed that intragastric administration of CIG (30, 60, and 120 mg/kg) for 3 months significantly increased the discrimination index in ORT and decreased the escape latency in MWM test, ameliorating the learning and memory deficit in 2VO rats. Further data indicated that CIG increased the expression of neurotrophic factors (NGF and BDNF) and their receptors (TrkA and TrkB), glutamate receptor subunits (NMDAR1 and GluR2) in the cerebral cortex and hippocampus of 2VO rats. In addition, CIG elevated the expression of PI3K subunits p110α and p85, fur...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research