Influenza vaccine effectiveness estimates against influenza A(H3N2) and A(H1N1) pdm09 among children during school-based outbreaks in the 2016 –2017 season in Beijing, China

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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research

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Mark K. Slifka1* and Ian J. Amanna2 1Division of Neuroscience, Oregon National Primate Research Center, Oregon Health &Science University, Beaverton, OR, United States2Najít Technologies, Inc., Beaverton, OR, United States Vaccines play a vital role in protecting our communities against infectious disease. Unfortunately, some vaccines provide only partial protection or in some cases vaccine-mediated immunity may wane rapidly, resulting in either increased susceptibility to that disease or a requirement for more booster vaccinations in order to maintain immunity above a protective level. The durability of a...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions: Human challenge studies and systems biology approaches are important tools that should be used in concert to advance our understanding of influenza infection and provide targets for novel therapeutics and immunizations. Introduction Although influenza virus was recognized as an important pathogen over a century ago, influenza continues to cause a significant burden of disease. In the United States alone, it's estimated that in the 2017–2018 season there were 959,000 hospitalizations related to influenza illness, and 79,400 deaths (CDC, 2018). Worldwide, WHO estimates that annual influenza...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
(CNN) — Flu activity remains high across the nation, and there’s a second wave of severe infections striking some states. There were as many as 26.3 million flu illnesses, 12.4 million medical visits and 347,000 flu hospitalizations between October 1 and March 2, according to the weekly flu report released Friday by the US Centers for Disease Control and Prevention. “We’re still having flu. And we’re still seeing a steady stream of patients who are being admitted to hospital with influenza,” said Dr. William Schaffner, medical director of the National Foundation for Infectious Diseases. ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Flu Source Type: news
The flu season is up and running in the Northern Hemisphere, and early signs in both the United States and Europe are that the effects might not be quite as severe as the brutal 2017/18 season. The United States is predominantly seeing H1N1 circulating, while monitoring in Europe has identified co-circulation of H1N1 and H3N2—both varieties of Influenza A that should be covered by the seasonable vaccine. What if they weren’t though? Influenza A can be found in both human and animal populations, and it evolves rapidly through genetic mutation. Each year many humans rely on their country&a...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Source Type: news
After a relatively slow start to flu season, influenza activity is now widespread in nearly half of U.S. states. Twenty-four states and Guam were reporting widespread influenza activity — meaning the virus has spread to many parts of the state, regardless of severity — as of Dec. 29, the latest date included in the Centers for Disease Control and Prevention’s (CDC) weekly flu report. Meanwhile, 19 states and New York City were reporting high levels of influenza-like illness activity, meaning a much higher-than-average proportion of doctor’s visits could be attributed to the flu. Nationally, about 4%...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime public health Source Type: news
Influenza has been impacting public health on a global scale since the beginning of recorded history. Influenza, also known as the “flu,” has numerous organizations committed to public health research, developing vaccines, and educating on best practices to prepare for the upcoming flu season. By gaining an understanding of the flu through history, virology, and how it impacts our society, we can have a better appreciation for the commitment that’s involved with combating the flu. What Is Influenza (and What’s Not)? The eyes of an epidemiologist can twitch for a variety of reasons, one of them being...
Source: JEMS Special Topics - Category: Emergency Medicine Authors: Tags: Exclusive Articles Operations Source Type: news
AbstractVaccination is an essential tool in reducing the impact of seasonal influenza infections. The viral strains responsible for seasonal outbreaks vary annually, and preventive vaccines have to be adapted accordingly. The aim of this study was to evaluate the safety, clinical tolerability and the antibody response to each of the three influenza vaccine antigens after vaccination with a cell-derived, trivalent, surface antigen, inactivated influenza vaccine (TIVc), as measured by single radial haemolysis (SRH) or haemagglutination inhibition (HI) assay in accordance with European Union licensing guidelines in place for ...
Source: Infection - Category: Infectious Diseases Source Type: research
Abstract The limited protection of current commerical vaccines necessitates the investigation of novel vaccine strategies for unpredictable outbreaks. To investigate the feasibility of using vaccines derived from Group 1 influenza A virus to induce broadly cross-reactive immune responses against multiple influenza subtypes, we tested a panel of sequential 4-dose immunization regimens in mice. Mice were treated with inactivated (seasonal H1N1, pandemic H1N1 and H5N1) and vaccinia virus-based H5N1 live-attenuated vaccines in different combinations. Mice were then challenged by viruses of either Group 1 (H1N1) or Gro...
Source: Virology - Category: Virology Authors: Tags: Virology Source Type: research
Introduction Following the initial outbreak of A/H1N1pdm09 in 2009-10, periodic resurgences of the pandemic influenza virus have been reported from India with variable morbidity and mortality. 1, 2 We have earlier reported a recrudescence of A/H1N1pdm09 in 2012-13 in Kashmir region of the northern Indian state of Jammu and Kashmir where influenza is an important cause of acute respiratory infections during the winter months. 3, 4 During the initial months of 2015, an unusual increase in influenza A/H1N1pdm09 activity was observed thoughout India with more than 39000 cases and about 3000 deaths. 5 While the activity was us...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
In this study, we attempted to generate a high growth influenza vaccine strain in MDCK cells using an A/Puerto/8/1934 (H1N1) vaccine seed strain. Following 48 serial passages with four rounds of virus plaque purification in MDCK cells, we were able to select several MDCK-adapted plaques that could grow over 108 PFU/ml. Genetic characterization revealed that these viruses mainly had amino acid substitutions in internal genes and exhibited higher polymerase activities. By using of a series of Rg viruses, we demonstrated the essential residues of each gene and identified a set of high-growth strains in MDCK cells (PB1D153N, M...
Source: Journal of Microbiology and Biotechnology - Category: Biotechnology Authors: Tags: J Microbiol Biotechnol Source Type: research
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