Generation of human induced pluripotent stem cells from peripheral blood mononuclear cells of a Senior-Loken syndrome patient

Publication date: Available online 1 November 2019Source: Stem Cell ResearchAuthor(s): Hyeyeon Park, Jinu Han, Youngsun Lee, Sungwook Kwak, Soo Kyung KooAbstractSenior-Loken syndrome (SLS) is a rare disorder primarily associated with kidney and retinal dysfunction. We generated a human induced pluripotency stem cell (hiPSC) line, designated DKHi005-A, from peripheral blood mononuclear cells of a patient with SLS using a Sendai virus reprogramming method. We confirmed that DKHi005-A cells harbor the same mutation as the patient and show a normal karyotype. DKHi005-A also has pluripotency and the capacity for differentiation into the three germ layers. This cell line is registered and available at the National Stem Cell Bank, Korea National Institute of Health.
Source: Stem Cell Research - Category: Stem Cells Source Type: research