An induced pluripotent stem cells line (SDQLCHi014-A) derived from urine cells of a patient with ASD and hyperactivity carrying a 303 kb de novo deletion at chr3p26.1 implicating GRM7 gene

Publication date: Available online 2 November 2019Source: Stem Cell ResearchAuthor(s): Xiaomeng Yang, Yong Liu, Tiancheng Zhou, Haiyan Zhang, Rui Dong, Yue Li, Ning Liu, Yi Liu, Zhongtao GaiAbstractAutism spectrum disorder (ASD) is a childhood-onset neurodevelopmental disorder challenged in social reciprocity and restrictive repetitive behaviors. Here, we generated an induced pluripotent stem cell (iPSC) line SDQLCHi014-A from a patient with ASD and hyperactivity, carrying a 303 kb de novo deletion at chr3p26.1 implicating GRM7 gene by reprogramming urine cells with non-integrating vectors. SDQLCHi014-A have shown full pluripotency, differentiation capacity and genetic stability. This iPSC line provides a valuable resource to study the molecular mechanisms underlying ASD.
Source: Stem Cell Research - Category: Stem Cells Source Type: research