Skin and soft tissue infections caused by different genotypes of PVL-positive community-acquired methicillin-resistant Staphylococcus aureus strains.

Skin and soft tissue infections caused by different genotypes of PVL-positive community-acquired methicillin-resistant Staphylococcus aureus strains. Jpn J Infect Dis. 2019 Oct 31;: Authors: Hanawa T, Shimoda-Komatsu Y, Araki K, Ohyama M, Onishi H, Kamiya S, Matsuda T Abstract Panton-Valentine leukocidin (PVL) is a causative agent of lethal necrotizing pneumonia and is associated with epidemic strains of community-acquired (CA) methicillin-resistant Staphylococcus aureus (MRSA). PVL-producing strains have rarely been isolated in Japan. However, the isolation frequency of PVL-positive CA-MRSA has been rapidly increasing in recent years. To investigate the relevance of the pvl genes (lukS/F-PV) and clinical traits in epidemic S. aureus strains, we genotyped four PVL-positive CA-MRSA strains isolated from patients with skin and soft tissue infections and measured their susceptibility to antibiotics. Three of the isolates matched the genotype of the USA300 clone, which has predominantly been isolated in the USA. The remaining strain matched the ST217 genotype and its spa type was identical to that of PVL-positive strains previously reported in India and China. Abscess drainage was necessary in all cases and deep cutaneous ulcers were formed in three out of four cases regardless of the genotype. The ST217 genotype strain was resistant to clindamycin in addition to quinolones, macrolides and aminoglycosides. Thus, diagnostic determination ...
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research