SAP102 contributes to hyperalgesia formation in the cancer induced bone pain rat model by anchoring NMDA receptors

This study investigated the role of SAP102 in the formation of hyperalgesia in rats with CIBP SAP102 is present in spinal dorsal horn neurons, but not in astrocytes or microglia. NMDAR-NR2B is localized with neurons. In addition, SAP102 and NMDAR-NR2B expression levels in spinal dorsal horn tissues were detected by Western blot and co-immunoprecipitation. Intrathecal injection of lentiviral vector of RNAi to knockdown SAP102 expression in the spinal dorsal horn significantly attenuated abnormal mechanic pain when compared to non-coding lentiviral vector. These findings indicate that SAP102 can anchor NMDA receptors to affect hyperalgesia formation in bone cancer pain.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research

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Publication date: November 2020Source: Biomedicine &Pharmacotherapy, Volume 131Author(s): Wei Gu, Yu’e Sun, Wanjie Gu, Yulin Huang, Jinhua Bo, Luyang Zhou, Zhengliang Ma, Xiaoping Gu, Wei Zhang
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: Intrathecal pioglitazone administration alleviates BCP by regulating the PPARγ/PTEN/mTOR signal in the SDH. Our data provided new insight in the therapeutic strategy in BCP management. PMID: 32942156 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
The authors have retracted this article [1] because in further experiments, they found that some experimental data cannot be verified repeatedly.
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 13 August 2020Source: Journal of Advanced ResearchAuthor(s): Wen-Ling Dai, Yi-Ni Bao, Ji-Fa Fan, Bin Ma, Shan-Shan Li, Wan-Li Zhao, Bo-Yang Yu, Ji-Hua Liu
Source: Journal of Advanced Research - Category: Research Source Type: research
Cancer pain is one of the most common and serious symptoms of cancer patients. At present, the agents used for the prevention or treatment of cancer pain do not act with optimal safety and efficacy. The nuclear factor kappa B (NF-κB) signaling pathway and its downstream inflammatory factors interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) play an important regulatory role in the developmental process of cancer pain. IKKβ is a key molecule of the IκB (IKK) kinase that propagates cellular responses to inflammation. Previous studies have shown that phosph...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Robust activation of glial cells has been reported to occur particularly during the pathogenesis of bone cancer pain (BCP). Researchers from our group and others have shown that histone deacetylases (HDACs) pl...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research
Bone cancer pain (BCP) is one of the most common types of chronic cancer pain and its pathogenesis has not been fully understood. Long non-coding RNAs (lncRNAs) are new promising targets in the field of pain r...
Source: Molecular Brain - Category: Neuroscience Authors: Tags: Research Source Type: research
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Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
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Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
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