Opposing effects of STAT3 targeting in epidermolysis bullosa.

Opposing effects of STAT3 targeting in epidermolysis bullosa.
Br J Dermatol. 2019 Nov 01;:
Authors: Mittapalli VR, Kühl T, Kuzet SE, Gretzmeier C, Kiritsi D, Gaggioli C, Bruckner-Tuderman L, Nyström A
Abstract
Dystrophic epidermolysis bullosa (DEB) is a skin blistering disease caused by mutations in the COL7A1 gene encoding the anchoring fibril-constituent collagen VII.1 Secondary to skin fragility, DEB manifests as chronic wounds and progressive soft tissue fibrosis. As a consequence of a chronically injured and stiffened dermal microenvironment people with severe DEB are prone to develop early-onset metastatic cutaneous squamous cell carcinomas (cSCCs).1,2 Dermal fibrosis in DEB is paradigmatic of injury- and inflammation-driven activation of fibrogenic processes2 (and references therein).
PMID: 31675440 [PubMed - as supplied by publisher]

Source: The British Journal of Dermatology - October 31, 2019 Category: Dermatology Authors: Mittapalli VR, Kühl T, Kuzet SE, Gretzmeier C, Kiritsi D, Gaggioli C, Bruckner-Tuderman L, Nyström A Tags: Br J Dermatol Source Type: research