Possible Fix Found For Arthritis Drug Side Effects

The drug rofecoxib (Vioxx), an anti-inflammatory drug used for arthritis, was previously taken off the US market because of serious cardiovascular side effects. However, new research has found that the class of drugs known as COX-2 inhibitors may yet be made safer. COX-2 inhibitors are used to reduce arthritis pain...
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Arthritis / Rheumatology Source Type: news

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WEDNESDAY, April 8, 2020 -- Folks with knee arthritis will get more out of physical therapy than a cortisone shot, a new clinical trial argues. People with osteoarthritis of the knee had less pain and disability after one year of physical therapy...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Conditions:   Knee Pain;   Chronic Osteoarthritis;   Avascular Necrosis of the Femoral Condyle;   Moderate Varus, Valgus or Flexion Deformities;   Rheumatoid Arthritis Interventions:   Procedure: Device: Persona Total Knee;   Procedure: Device: NexGen Total Knee;   Procedure: Device: Vanguard Total Knee Sponsor:   Zimmer Biomet Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractAssessment of individual therapeutic responses provides valuable information concerning treatment benefits in individual patients. We evaluated individual therapeutic responses as determined by the Disease Activity Score-28 joints critical difference for improvement (DAS28-dcrit) in rheumatoid arthritis (RA) patients treated with intravenous tocilizumab or comparator anti-tumor necrosis factor (TNF) agents. The previously published DAS28-dcrit value [DAS28 decrease (improvement)  ≥ 1.8] was retrospectively applied to data from two studies of tocilizumab in RA, the 52-week ACT-iON observational stud...
Source: Rheumatology International - Category: Rheumatology Source Type: research
Abstract Chronic inflammatory pain is a serious clinical problem caused by inflammation of the joints and degenerative diseases and greatly affects patients' quality of life. Persistent pain states are thought to result from the central sensitization of nociceptive pathways in the spinal dorsal horn. Spinal microglia-mediated neuroinflammation plays a pivotal role in the development and maintenance of the central sensitization of chronic inflammatory pain. Botulinum toxin type A (BoNT/A) was recently reported to have analgesic and anti-inflammatory effects. However, the precise mechanism underlying its analgesic e...
Source: Toxicon - Category: Toxicology Authors: Tags: Toxicon Source Type: research
ConclusionsThe prevalence and impact of medical comorbidity on PROs are very high in patients with PsA.
Source: Rheumatology and Therapy - Category: Rheumatology Source Type: research
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Source: Psychology, Health and Medicine - Category: International Medicine & Public Health Authors: Source Type: research
Publication date: Available online 5 April 2020Source: Journal of EthnopharmacologyAuthor(s): Felipe Marques Teixeira, Mariana Neubarth Coelho, Fernanda do Nascimento José-Chagas, David do Carmo Malvar, Alexandre Kanashiro, Fernando de Queiroz Cunha, Marcelo Dias Machado Vianna-Filho, Angelo da Cunha Pinto, Frederico Argollo Vanderlinde, Sônia Soares Costa
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
DUBLIN, April 6, 2020 -- (Healthcare Sales &Marketing Network) -- Perrigo Company plc (NYSE: PRGO; TASE) today announced that it was the first to receive approval from the U.S. Food and Drug Administration for its abbreviated new drug application (ANDA) ... Biopharmaceuticals, Generics, FDA Perrigo, Voltaren, Voltaren Gel, diclofenac
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
CONCLUSIONS: In EUA, physical and mood disorders are associated with new and old inflammatory serological, clinical and imaging biomarkers. HLA-DRB1*11-positivity may be protective against these disease-related features. PMID: 32242813 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: Moreno-Fresneda P, Triguero-Martínez A, Olivas-Martínez I, Ortiz-Aljaro P, González-Escribano MF, Nuño-Nuño L, Ortiz AM, González-Álvaro I Abstract OBJECTIVES: To investigate the role of body mass index (BMI) in the phenotypic and genotypic characteristics of early arthritis patients. METHODS: We analysed the clinical and laboratory parameters from the baseline visit of patients (670 patients [78.51% women]) included in the PEARL study. The WHO definition for low weight, normal weight, overweight and obesity (BMI
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
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