Identifying signatures of the impact of rotavirus vaccines on hospitalizations using sentinel surveillance data from Latin American countries.
CONCLUSIONS: The combination of methods we applied have different strengths that allow us to identify common signatures of rotavirus vaccine impact. PMID: 31672333 [PubMed - as supplied by publisher]
Abstract Rotaviruses are the most common infectious agents causing severe diarrheal diseases in young children globally. Three rare human rotavirus strains, two G3P and one G3P, were detected in stool samples of children under 5 years of age hospitalized for gastroenteritis in Lebanon during the course of a surveillance study. Complete genomes of these strains were sequenced using VirCapSeq-VERT, a capture based high-throughput sequencing method. Genomic sequences were further characterized by using phylogenetic analyses with global RVA G3P/P strains, other vaccine and reference strains. Genetic anal...
Condition: Rotavirus Gastroenteritis Interventions: Biological: Rotavirus RV3 Vaccine (Bio Farma); Other: Placebo Sponsor: PT Bio Farma Not yet recruiting
Conclusions: Our review highlights similarities and differences in the application of the test-negative design that deserve further examination. If vaccination reduces disease severity in breakthrough infections, particular care must be taken in interpreting vaccine effectiveness estimates from test-negative design studies.
With rotavirus vaccination rates lagging behind those of other childhood vaccines, many children still suffer from severe rotavirus disease. Here are five things to know.CDC Expert Commentary
This study suggests a limited impact of gut microbial taxa on response to oral rotavirus vaccination among infants; however, additional research is needed to improve our understanding of the impact of gut microbiome on vaccine response, toward a goal of improving vaccine efficacy and rotavirus prevention. PMID: 31802728 [PubMed - as supplied by publisher]
This study examined the RV vaccine effectiveness against risk of hospitalization based on a retrospective cohort study and the impact of public expense for the RV vaccine on this regional RV gastroenteritis epidemic. The vaccination coverage was significantly higher in children in Shari and Koshimizu than in Abashiri (87.8% vs. 42.7%, respectively, p
Human group A rotavirus is the leading cause of severe acute gastroenteritis in young children worldwide. Immunization programs have reduced the disease burden in many countries. Vaccination coverage in the Au...
Conclusions: The present study found RVA positivity in 30.62% of children with gastroenteritis, with the highest burden among 24–36 months old. The predominant genotypes were G1, G3, and P. Further large-scale/multicentric studies should be conducted to document the diversity of circulating RVA genotypes in this region for giving inputs for vaccination strategy.
Authors: Kotsopoulos N, Haitsma G, Connolly MP, Standaert B Abstract Background: The economics of rotavirus gastroenteritis in infants