Total Gastrectomy for CDH-1 Mutation Carriers: An Institutional Experience

Gastric cancer is a leading cause of cancer-related death across the world. A subset of gastric cancers demonstrates an inherited genetic predisposition. Individuals with germline mutations in the CDH1 gene incur a lifetime risk for diffuse gastric cancer and benefit from prophylactic gastrectomy. The results for this operative intervention remain relatively undescribed in the literature, despite guidelines supporting its use.

Source: Journal of Surgical Research - October 31, 2019 Category: Surgery Authors: Sandra R. DiBrito, Alex B. Blair, Vishnu Prasath, Mehran Habibi, John W. Harmon, Mark D. Duncan Source Type: research