Role of Sleep on Motor Learning in Parkinson's Disease and Healthy Older Adults

Conditions:   Parkinson Disease;   Aging Interventions:   Behavioral: NAP;   Behavioral: WAKE Sponsor:   KU Leuven Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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AbstractThe non-motor features of Parkinson ’s disease (PD) are increasingly being recognised. This review deals with the spectrum of sleep disorders associated with PD, which have a multifactorial aetiology and can significantly have an impact on the quality of life of patients and their carers. Some sleep disorders represent a prodromal p hase of PD, with REM sleep behaviour disorder (RBD) being of particular interest in this regard, whereas others become more common as the disease advances. Understanding the pathophysiology of these sleep disturbances will hopefully lead to new treatment opportunities in the futur...
Source: Journal of Neurology - Category: Neurology Source Type: research
AbstractObjectiveWe aimed to determine suicide risk and lifetime suicidal ideation in Parkinson disease (PD) patients versus controls and how depression, demoralization, and insomnia are associated with suicidality.MethodsIn this case –control study, PD patients and matched controls were recruited from movement disorder clinics, Michael J. Fox Foundation, and Research Match websites. Suicide risk and suicidal ideation were assessed using the Suicidal Behavior Questionnaire-revised (SBQ-R) and Columbia-Suicide Severity Rating Sc ale. Lifetime depression was assessed using the Brief Lifetime Depression Scale, sleep usi...
Source: Journal of Neurology - Category: Neurology Source Type: research
AbstractThere is sufficient evidence that the pathological process that causes Parkinson ’s disease begins years before the clinical diagnosis is made. Over the last 15 years, there has been much interest in the existence of a prodrome in some patients, with a particular focus on non-motor symptoms such as reduced sense of smell, REM-sleep disorder, depression, and constipation. Give n that the diagnostic criteria for Parkinson’s disease depends on the presence of bradykinesia, it is somewhat surprising that there has been much less research into the possibility of subtle motor dysfunction as a pre-diagnos...
Source: Journal of Neurology - Category: Neurology Source Type: research
We aimed to assess, in patients with Parkinson's disease (PD), the association between obstructive sleep apnea (OSA), progression of motor dysfunction and the effect of OSA treatment.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
Sleep disorders are frequently diagnosed in Parkinson’s disease and manifested in the prodromal and advanced stages of the disease. These conditions, which in some cases affect more than 50% of Parkinson’s disease (PD) patients, include hypersomnia, often manifested as excessive daytime sleepiness, insomnia, characterized by delayed initiation and fragmentation of sleep at night, and disruption of rapid eye movement (REM) sleep, resulting in loss of atonia and dream enactment. Standard dopamine replacement therapies for the treatment of motor symptoms are generally inadequate to combat sleep abnormalities, whic...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This review aimed to determine the efficacy of therapeutic interventions for the management of cognition, mood, and sleep impairments in individuals with PD. This systematic review guided program development at a local YMCA discussing PD and therapeutic non-pharmalogical interventions for cognition, mood, and sleep.
Source: Archives of Physical Medicine and Rehabilitation - Category: Rehabilitation Authors: Tags: Late breaking systematic/meta-analytic review poster Source Type: research
Conclusions: In the PD rat model, CIH will activate TREM-1 positive cells and systemic inflammation, resulting in dopaminergic neuron apoptosis in substantial nigra, worsening dopaminergic neurodegeneration in striatum, and impairing motor coordination. These findings indicate a novel mechanistic pathway that mediates OSA and PD comorbidity.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research
What exactly is psychosis? What happens in the brain of a person with schizophrenia who is hallucinating? Schizophrenic Rachel Star Withers shares her personal hallucinations and delusions and Dr. Joseph Goldberg, who specializes in researching what goes on in the brain when someone is experiencing psychosis, joins to break down how the brain functions during psychotic episodes. Host Rachel Star Withers, a diagnosed schizophrenic, and co-host Gabe Howard delve into these intense subjects in this episode of Inside Schizophrenia.  Highlights from “Psychosis in Schizophrenia” Episode [02:13]  Rachel, do...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior Disorders General Inside Schizophrenia Mental Health and Wellness Active psychosis Delusions Delusions Hallucinations Living with Schizoprenia Mental Disorder Mental Illness Psychology psychotic Psychotic Break Source Type: blogs
In a presentation Tuesday at the XXIV World Congress of Neurology in Dubai, researchers from the Center for Neurodegenerative Science at Van Andel Institute in Grand Rapids, Mich., told more than 4,000 neurologists.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
CONCLUSION: As it is detected by a survey performed by telephone calls with good interrater reliability, patients with PD gets better with LCIG treatment in many aspects of the disease. PMID: 31731332 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
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