Effects of Haplotype Matching on Outcomes after Adult Single-Cord Blood Transplantation

Unrelated cord blood (UCB) has been established as an alternative source of hematopoietic stem cells for adult and pediatric allogeneic hematopoietic cell transplant [1-15]. One of the advantages of UCB transplantation (UCBT) is the less stringent requirement for HLA matching compared with that in bone marrow or peripheral blood stem cell transplant under standard graft-versus-host disease (GVHD) prophylaxis, which makes it easier to find candidate UCB units. Another advantage of UCBT is lower incidences of acute and chronic GVHD despite multiple HLA mismatches and better responses to corticosteroid treatment for acute GVHD compared with peripheral blood stem cell transplant.

Source: Biology of Blood and Marrow Transplantation - October 8, 2019 Category: Hematology Authors: Junya Kanda, Takakazu Kawase, Hidenori Tanaka, Hiroto Kojima, Yasuo Morishima, Naoyuki Uchida, Koji Nagafuji, Yoshiko Matsuhashi, Takanori Ohta, Makoto Onizuka, Toru Sakura, Satoshi Takahashi, Shigesaburo Miyakoshi, Hikaru Kobayashi, Tetsuya Eto, Junji Ta Source Type: research