Preclinical Evidence for Targeting PI3K/mTOR Signaling with Dual-Inhibitors as a New Therapeutic Strategy against Cutaneous T Cell Lymphoma
The PI3K/AKT/mTOR pathway is hyperactivated in many tumors, as well as in cutaneous T-cell lymphoma (CTCL) which includes mycosis fungoides (MF) and the aggressive variant known as Sezary syndrome (SS). TORC1 signaling is activated in SS cells by cytokines and chemokines, which are overexpressed in SS tissues. Furthermore, the recurrent copy number variation (CNV) of genes belonging to this cascade, such as PTEN, LKB1, and P70S6K, contributes to the hyperactivation of the pathway. The aim of this study was to investigate the therapeutic potential of mTOR inhibitors in CTCL.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Antonella Bresin, Cristina Cristofoletti, Elisabetta Caprini, Maria Cantonetti, Alessandro Monopoli, Giandomenico Russo, Maria Grazia Narducci. Tags: Original Article Source Type: research
More News: Cutaneous T cell lymphoma | Dermatology | Genetics | Lymphoma | Mycosis Fungoides | Sezary Syndrome | Skin | Study | T-cell Lymphoma