GSE138632 Role of Mineralocorticoid Receptor (Nr3c2) in Adipogenesis and Obesity in Male Mice

Contributors : Charles A Harris ; Daniel FergusonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIncreased visceral adiposity and hyperglycemia, two characteristics of metabolic syndrome, are also present in conditions of excess glucocorticoids (GCs). GCs are hormones thought to act primarily via the glucocorticoid receptor (GR). GCs are commonly prescribed for inflammatory disorders, yet their use is limited due to many adverse metabolic side effects. In addition to GR, GCs also bind the mineralocorticoid receptor (MR), but there are many conflicting studies as to the exact role of MR in metabolic disease. Using MR knockout mice (MRKO), we find that both white and brown adipose depots form normally when compared to wild-type mice at P5. We created mice with adipocyte-specific deletion of MR (FMRKO) to better understand the role of MR in metabolic dysfunction. Treatment of mice with excess GCs for 4 weeks, via corticosterone in drinking water, induced increased fat mass and glucose intolerance to similar levels in FMRKO and floxed-control mice. Separately, when fed a high-fat diet for 16 weeks, FMRKO mice had reduced body weight, fat mass, and hepatic steatosis, relative to floxed-control mice. Decreased adiposity likely resulted from increased energy expenditure since food intake was not different. RNA sequencing analysis revealed decreased enrichment of genes associated with adipogenesis in inguinal white adipose of FMRKO mice. Differe...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

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Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Tags: Environ Sci Pollut Res Int Source Type: research
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Source: Diabetes Therapy - Category: Endocrinology Source Type: research
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Source: Singapore Medical Journal - Category: General Medicine Authors: Tags: Singapore Med J Source Type: research
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Source: Physiological Research - Category: Physiology Authors: Tags: Physiol Res Source Type: research
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Source: Current Eye Research - Category: Opthalmology Authors: Tags: Curr Eye Res Source Type: research
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Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Endocrinology Authors: Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
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Source: Women and Health - Category: Primary Care Authors: Tags: Women Health Source Type: research
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