84-Year-Old Man With Headache, Nausea, and Syncope

An 84-year-old man with gastroesophageal reflux disease, hypothyroidism, benign prostatic hyperplasia, chronic constipation, and acute  myelogenous leukemia with myelodysplastic-related changes including chronic anemia, currently in remission, presented to the emergency department for the evaluation of an unwitnessed fall. The patient's wife had been in the adjoining room and reported hearing the patient fall and found him on the floor next to his chair at the kitchen table. She did not observe any abnormal or rhythmic movements.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Residents' clinic Source Type: research

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This study confirmed consistent early onset of efficacy for fremanezumab in chronic migraine prevention, providing potential to improve patient compliance and clinical outcomes.Headache
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news
Saima Herz, 30, woke up one morning feeling feverish with a throbbing headache before she went to her GP and was told she'd picked up a virus.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print
Source: Clinical Chemistry and Laboratory Medicine - Category: Laboratory Medicine Source Type: research
In a previous life in the 1970s, I was a blood banker at a large academic hospital. This may sound unbelievable to some of the currentLab Soft News readers but one of our cardiac surgeons in the 1970's would often transfuse six or more units of blood during a CABG (see: Variation in Use of Blood Transfusion in Coronary Artery Bypass Graft Surgery). Although modern blood transfusion can be life-saving, it can sometimes be a substitute for controlling hemorrhage by other and more appropriate means. In other words, less transfusion can often be equated with higher quality care. There is also a financial benefit when a hos...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Tags: Blood banking Clinical Lab Industry News Cost of Healthcare Lab Industry Trends Medical Research Quality of Care Source Type: blogs
β-Thalassemia is a genetic anemia caused by partial or complete loss of β-globin synthesis, leading to ineffective erythropoiesis and RBCs with a short life span. Currently, there is no efficacious oral medication modifying anemia for patients with β-thalassemia. The inappropriately low levels of the iron regulatory hormone hepcidin enable excessive iron absorption by ferroportin, the unique cellular iron exporter in mammals, leading to organ iron overload and associated morbidities. Correction of unbalanced iron absorption and recycling by induction of hepcidin synthesis or treatment with hepcidin mimetics ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
ConclusionsAt the 400 μg dose level no substantial changes in PD parameters were noted. Extrapolating from pre-clinical data, the dose examined in this cohort was too low to achieve the Se plasma concentration (≥ 5 μM) expected to elicit significant PD effects. Recruitment of a subsequent cohort at higher doses to exceed this PK threshold is planned.
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
AbstractAccess to reliable, up-to-date information and resources can assist individuals managing and living with cancer. The Leukemia&Lymphoma Society, through its Information Resource Center, provides personalized information and support to individuals affected by blood cancer. To examine its value and impact, we conducted qualitative interviews (n = 18) and an online survey of patients and caregivers (N = 515) after they talked with an Information Resource Center Information Specialist by phone, with a follow-up survey about 6 months later. Respondents most commonly contacted the Information Resource Center to get re...
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
Hashimoto autoimmune thyroiditis (AIT) is the most common cause of acquired hypothyroidism in the pediatric population. Development of AIT is mediated mainly by cellular immune response directed toward thyroid autoantigens, leading to inflammation and impaired function of thyroid gland. Both thyroid dysfunction and inflammation affect the metabolism of plasma lipoproteins. The alterations in lipid profile worsen with the advancement of hypothyroidism, ranging from discrete changes in euthyroid AIT patients, to atherogenic dyslipidemia in the overt hypothyroidism. In this review, characteristics of dyslipidemia in pediatric...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
We investigated the local immune status and its prognostic value in lung adenocarcinoma. In total, 513 lung adenocarcinoma samples from TCGA and ImmPort databases were collected and analyzed. The R package coxph was employed to mine immune-related genes that were significant prognostic indicators using both univariate and multivariate analyses. The R software package glmnet was then used for Lasso Cox regression analysis, and a prognosis prediction model was constructed for lung adenocarcinoma; clusterProfiler was selected for functional gene annotations and KEGG enrichment analysis. Finally, correlations between the RiskS...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: Based on shared epidemiological and biological features, B-cell acute lymphoblastic leukemia with t(5;14)(q31;q32) is a peculiar subset of IGH-rearranged B-cell acute lymphoblastic leukemia with an intermediate prognosis and particular clinical features related to eosinophilia.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
More News: Acid Reflux | Acute Leukemia | Anemia | Benign Prostatic Hyperplasia | Chronic Leukemia | Constipation | Emergency Medicine | Gastroenterology | Gastroesophageal Reflux Disease | GERD | Headache | Hypothyroidism | Internal Medicine | Leukemia | Migraine