iRhom2 and TNF: Partners or enemies?

iRhom2 and TNF: Partners or enemies?
Sci Signal. 2019 Oct 29;12(605):
Authors: Badenes M, Adrain C
Abstract
iRhom2 is an essential cofactor for ADAM17, the metalloprotease that sheds both the proinflammatory cytokine tumor necrosis factor-α (TNF-α) and TNF receptors (TNFRs) from the cell surface. In this issue of Science Signaling, Sundaram et al. demonstrate a protective role for iRhom2 in promoting ADAM17-mediated shedding of TNFRs in hepatic stellate cells, which reduces TNFR signaling and liver fibrosis in response to injury.
PMID: 31662485 [PubMed - in process]

Source: Science Signaling - October 28, 2019 Category: Biomedical Science Authors: Badenes M, Adrain C Tags: Sci Signal Source Type: research