Revision After Total Transmetatarsal Amputation

Publication date: November 2019Source: The Journal of Foot and Ankle Surgery, Volume 58, Issue 6Author(s): Peter Kaiser, Thomas Vincent Häller, Ilker Uçkay, Dominik Kaiser, Martin Berli, Thomas Böni, Felix WaibelAbstractTotal transmetatarsal amputation (TMA) can be an option for foot salvage in gangrene, sepsis, or infected necrosis. However, the literature concerning predictive outcome factors and bacterial sampling is scarce. To identify potential associations between revision surgery and underlying bacteria or other preoperative selection criteria, we reviewed all patients with TMA who were treated at our institution. We compared the patients with remissions with surgical revisions. Among 96 adult patients with TMA (105 amputations), 42 required a revision surgery (40%), 18 had a further minor proximal surgical reamputation (17%) and 18 had a major proximal surgical reamputation (14%). In group comparisons, a previous infection with Staphylococcus aureus was protective with a lower revision risk (4/26 with revision surgery vs 22/26 without revisions; p = .03). This was the opposite for postoperative persistent soft tissue or bone infections (p
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research

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Source: Psychology, Health and Medicine - Category: International Medicine & Public Health Authors: Source Type: research
Source: Psychology, Health and Medicine - Category: International Medicine & Public Health Authors: Source Type: research
Basel, 16 December 2019 - Roche (SIX: RO, ROG; OTCQX: RHHBY) and Spark Therapeutics, Inc. (NASDAQ: ONCE) ( “Spark”) today announced that the UK Competition and Markets Authority has unconditionally cleared Roche’s pending acquisition of Spark pursuant to its previously announced tender offer to purchase all of the outstanding shares of common stock (the “Shares”) of Spark for USD 114.50 per Sha re, net to the seller thereof in cash, without interest and subject to any withholding taxes required by applicable law and upon the terms and subject to the conditions set forth in the Offer to Purchas...
Source: Roche Media News - Category: Pharmaceuticals Source Type: news
IV propofol anesthesia is widely used for painless GI endoscopy, but low oxygen saturation may result. Can doxapram alleviate low SpO2 in this scenario?BMC Anesthesiology
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Publication date: Available online 14 December 2019Source: NeuroscienceAuthor(s): Julie Duron, Lénaic Monconduit, Paul AvanAbstractHyperacusis, an exaggerated, sometimes painful perception of loudness even for soft sounds, is a poorly understood distressing condition. While the involvement of modified gain of central auditory neurons and the influence of nonauditory brain regions are well-documented, the issue of where in the auditory system these abnormalities arise remains open, particularly when hyperacusis comes without sensorineural hearing loss. Here we used acute intraperitoneal administration of sodium salic...
Source: Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 14 December 2019Source: NeuroImageAuthor(s): Henriette Lambers, Martin Segeroth, Franziska Albers, Lydia Wachsmuth, Timo Mauritz van Alst, Cornelius FaberAbstractFor a reliable estimation of neuronal activation based on BOLD fMRI measurements an accurate model of the hemodynamic response is essential. Since a large part of basic neuroscience research is based on small animal data, it is necessary to characterize a hemodynamic response function (HRF) which is optimized for small animals. Therefore, we have determined and investigated the HRFs of rats obtained under a variety of experimenta...
Source: NeuroImage - Category: Neuroscience Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Conclusion: The relationship between CH and hyperinsulism has implications for clinical practice as it might help to establish the correct diagnosis in neonates with cardiac hypertrophy which has both prognostic and therapeutic consequences. In addition, CH should be recognized as a potential comorbidity which might necessitate treatment in all neonates with known hyperinsulinism.What is Known:•Hyperinsulinism is currently not acknowledged as a cause of hypertrophic cardiomyopathy (HCM) in textbooks and recent Pediatric Cardiomyopathy Registry publications.What is New:•This article presents an overview of the lit...
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
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Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
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