A Distance-Based Neurorehabilitation Evaluation Method Using Linear SVM and Resting-State fMRI

During neurorehabilitation, clinical measurements are widely adopted to evaluate behavioral improvements after treatment. However, it is not able to identify or monitor the change of central nervous system (CNS) of each individual patient. Resting-state functional magnetic resonance imaging (rs-fMRI) has been widely used to investigate brain functions in healthy controls (HCs) and patients with neurological diseases, which could find functional changes following neurorehabilitation. In this paper, a distance-based rehabilitation evaluation method based on rs-fMRI was proposed. Specifically, we posit that in the functional connectivity (FC) space, patients and HCs distribute separately. Linear support vector machines (SVM) were trained on the brain networks to firstly separate patients from HCs. Second, the FC similarity between patients and HCs was measured by the L2 distance of each subject's feature vector to the separating hyperplane. Finally, statistical analysis of the distance revealed rehabilitation program induced improvements in patients and predicted rehabilitation outcomes. An rs-fMRI dataset with 22 HCs and 18 spinal cord injury (SCI) patients was utilized to validate our method. We built whole-brain networks using five atlases to test the robustness of the method and search for features under different node resolutions. The classifier successfully separated patients and HCs. Significant improvements in FC after treatment were found for the patients for all five a...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
AbstractTree shrews, possessing higher developed motor function than rats, were more suitable to study neurological behavior after spinal cord injury (SCI). Here, we established a feasible behavioral assessment method to detect the degree of ethology recovery in tree shrew subjected to spinal cord transection (SCT). Tree shrews were divided into normal group, sham group, and SCT group. The tree shrew in sham group was subjected to laminectomy without SCI, while the tree shrews in the SCT group were subjected to a complete SCT in thoracic 10 (T10). A novel neurobehavior assessment scale was established, in which, the behavi...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
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Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
The pathways of circulation and clearance of cerebrospinal fluid (CSF) in the spine have yet to be elucidated. We have recently shown with dynamic in vivo imaging that routes of outflow of CSF in mice occur along cranial nerves to extracranial lymphatic vessels. Here, we use near-infrared and magnetic resonance imaging to demonstrate the flow of CSF tracers within the spinal column and reveal the major spinal pathways for outflow to lymphatic vessels in mice. We found that after intraventricular injection, a spread of CSF tracers occurs within both the central canal and the spinal subarachnoid space toward the caudal end o...
Source: The Journal of Experimental Medicine - Category: Internal Medicine Authors: Tags: Cardiovascular Biology, Neuroscience Brief Definitive Reports Source Type: research
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Source: JAMA Neurology - Category: Neurology Source Type: research
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Source: Journal of Neurological Surgery Part B: Skull Base - Category: Neurosurgery Authors: Tags: Skull Base: Operative Videos Source Type: research
We present 2 cases of paraplegia due to NMO with rehabilitation outcome. Patient concerns: The first case corresponds to a 65-year-old woman with NMO presented with C4 incomplete American Spinal Injury Association (ASIA) scale D, and the second case is a 41-year-old woman with NMO presented with C1 incomplete ASIA-C. Diagnoses: Two cases were confirmed by positive anti-aquaporin-4 antibody and presence of T2-weighted hyperintense lesion in spinal cord on magnetic resonance imaging. Intervention: The first patient planned for focusing on left hand fine motor training through occupational therapy by strengthening an...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
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Source: European Spine Journal - Category: Orthopaedics Source Type: research
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Source: Canadian Family Physician Medecin de Famille Canadien - Category: Primary Care Authors: Tags: Can Fam Physician Source Type: research
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Source: Trials - Category: Research Source Type: clinical trials
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