Symptom Severity Impacts Sympathetic Dysregulation and Inflammation in Post-Traumatic Stress Disorder (PTSD)

Publication date: Available online 1 November 2019Source: Brain, Behavior, and ImmunityAuthor(s): Ida T. Fonkoue, Paul J. Marvar, Seth Norrholm, Yunxiao Li, Melanie L. Kankam, Toure N. Jones, Monica Vemulapalli, Barbara Rothbaum, J. Douglas Bremner, Ngoc-Anh Le, Jeanie ParkAbstractPost-traumatic stress disorder (PTSD) is associated with a greater risk of incident hypertension and cardiovascular disease. Inflammation, impaired baroreflex sensitivity (BRS) decreased parasympathetic nervous system (PNS) and overactive sympathetic nervous system (SNS) activity are suggested as contributing mechanisms. Increasing severity of PTSD symptoms has been linked to greater cardiovascular risk; however, the impact of PTSD symptom severity on inflammation and autonomic control of blood pressure has not yet been explored. We hypothesized that increasing PTSD symptom severity is linked to higher inflammation, greater SNS activity, lower PNS reactivity and impaired BRS. Seventy Veterans participated in this study: 28 with severe PTSD ((Clinical Administered PTSD Scale (CAPS)>60; S-PTSD), 16 with moderate PTSD (CAPS ≥ 45 ≤60; M-PTSD) and 26 Controls (CAPS
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research

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The combined operation of optokinetic reflex (OKR) and vestibular-ocular reflex (VOR) is essential for image stability during self-motion. Retinal slip signals, which provide neural substrate for OKR and VOR plasticity, are delivered to the inferior olive. Although it has been assumed that the neural circuitry and mechanisms underlying OKR and VOR plasticity are shared, differential role of the inferior olive in the plasticity of OKR and VOR has not been clearly established. To investigate the differential effect of inferior olive lesion on OKR and VOR plasticity, we examined the change of OKR and VOR gains after gain-up a...
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Cured ham consumption and incidence of hypertension: The "Seguimiento Universidad de Navarra" (SUN) cohort. Med Clin (Barc). 2019 Nov 29;: Authors: Rico-Campà A, Sayón-Orea C, Martínez-González MÁ, Ruiz-Canela M, Ruiz-Estigarribia L, de la Fuente-Arrillaga C, Toledo E, Bes-Rastrollo M Abstract BACKGROUND AND OBJECTIVES: Cured ham is one of the most characteristic foods in the Spanish diet. Because it is a red processed meat and due to its nutritional composition, including high sodium content, a potential association between cured ham consumption and a highe...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Abstract Post-traumatic stress disorder (PTSD) is associated with a greater risk of incident hypertension and cardiovascular disease. Inflammation, impaired baroreflex sensitivity (BRS) decreased parasympathetic nervous system (PNS) and overactive sympathetic nervous system (SNS) activity are suggested as contributing mechanisms. Increasing severity of PTSD symptoms has been linked to greater cardiovascular risk; however, the impact of PTSD symptom severity on inflammation and autonomic control of blood pressure has not yet been explored. We hypothesized that increasing PTSD symptom severity is linked to higher in...
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Tags: Brain Behav Immun Source Type: research
Post-Traumatic Stress Disorder (PTSD) dysregulates physiological systems leading to elevated sympathetic tone and norepinephrine (NE) outflow, pronounced inflammation, and a>50% increased risk in developing comorbid cardiovascular diseases like hypertension (HTN). We hypothesized that NE increases T-lymphocyte-driven inflammation leading to HTN after trauma exposure.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
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Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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