Herpes simplex virus reactivation and the relationship with Alzheimer's disease: A countering view

This commentary challenges the premise of a viral etiology in Alzheimer's disease by discussing evidence that Herpes simplex virus reactivation reduces progression to Alzheimer's disease, and also proposing that viral reactivation is a compensatory reaction to other causal exposures in Alzheimer's disease pathophysiology. AbstractMany have described the molecular mechanisms underpinning the viral etiology of Alzheimer's disease. This commentary challenges this premise by discussing evidence that Herpes simplex virus reactivation reduces progression to Alzheimer's disease, and also proposing that viral reactivation is a compensatory reaction to other causal exposures in Alzheimer's disease pathophysiology.

Source: Clinical and Experimental Neuroimmunology - October 31, 2019 Category: Neurology Authors: Keith Fluegge Tags: Commentary Source Type: research