The Nephroprotective Role of Carnosine Against Ifosfamide-Induced Renal Injury and Electrolytes Imbalance is Mediated Via the Regulation of Mitochondrial Function and Alleviation of Oxidative Stress

Conclusion Our data suggest mitochondrial dysfunction and oxidative stress as fundamental mechanisms of renal injury induced by IFO. On the other hand, carnosine supplementation protected kidneys against IFO-induced injury through regulating mitochondrial function and mitigating oxidative stress. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Drug Research - October 30, 2019 Category: Drugs & Pharmacology Authors: Ommati, Mohammad Mehdi Farshad, Omid Ghanbarinejad, Vahid Mohammadi, Hamid Reza Khadijeh, Mousavi Negar, Azarpira Zahra, Mahboubi Ilkhaninasab, Farshid Moezi, Leila Heidari, Reza Tags: Original Article Source Type: research