Reproductive outcomes following a stem cell transplant for a haematological malignancy in female cancer survivors: a systematic review and meta-analysis

ConclusionsThis meta-analysis reflects low pregnancy rates for cancer survivors desiring a family. However, live births are improving over time with new technology and novel therapies. Hence, female cancer patients should be offered timely discussions, counselling and education around fertility preservation options prior to starting treatment with gonadotoxic therapy.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research

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In 2018, the number of bacterial sexually transmitted infections (STIs) reported in the United States reached an all-time high. This is worrisome for many reasons. Having an STI can raise risks for HIV, infertility, pregnancy complications, and infant death. Fortunately, all of these outcomes can be avoided if people receive appropriate treatment. What are STIs? STIs are illnesses caused by microorganisms passed between people during sex. An STI can affect anyone who is exposed to it. Syphilis, gonorrhea, and chlamydia are the most common bacterial infections. Trichomoniasis, a protozoan infection, is also diagnosed freque...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Adolescent health HIV Men's Health Relationships Sexual Conditions Women's Health Source Type: blogs
This study raises serious concerns about whether we’ve been careful enough about the safety of this chemical,” said Patricia Hunt, a professor of molecular bioscience at Washington State, and a corresponding author of the paper, in a statement. Despite how huge the difference, the results are not getting much evident pushback from other researchers in the field. “It honestly blew my mind—not because I don’t believe it, but because it appears to be true,” says Lori Hoepner, assistant professor of environmental and occupational health sciences at SUNY Downstate School of Public Health. &ld...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized bisphenol a BPA endocrine disruptor Environment Environmental Health Source Type: news
This study has demonstrated higher PLAC1 levels in infertile women with RIF and RPL for the first time; suggesting that it could have a negative effect on implantation in these populations. PLAC1 could be detected in the serum as a biomarker that is associated with RIF and RPL. What are the implications of these findings for clinical practice and/or further research? Defining the precise role of PLAC1 during implantation will provide new insight into understanding of poor reproductive outcomes such as RIF and RPL and help in developing treatment strategies. Further large-scale studies with more patients are needed to uncov...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
ConclusionsWomen with an early stage of breast cancer and a possible future child wish should be referred to an expertise center in breast cancer, fertility preservation, and genetics in this complex decision-making process, shortly after diagnosis.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
UNFPA-supported midwives ensured that this young woman gave birth safely in Bor Hospital, South Sudan. © UNFPA South SudanBy Julitta OnabanjoJOHANNESBURG, South Africa, Nov 12 2019 (IPS) This is a special year for all rights-based health advocates, as we celebrate 25 years of the International Conference on Population and Development (ICPD). At the ICPD in Cairo in 1994, for the first time world leaders from 179 member states committed to the principles that underpin today’s Sustainable Development Goals: non-discrimination and universality; the centrality of health, including sexual and reproductive health and...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Africa Gender Headlines Health Population Poverty & SDGs TerraViva United Nations ICPD25 International Conference on Population and Development (ICPD25) Source Type: news
Purpose of review To investigate the JZE alterations in gynecological and obstetrical disorders and impact on diagnosis, prognosis and treatment. Recent findings JZE was found to be significantly extended in patients with endometriosis, leading to the conclusion that endometriosis is a primary disease of the uterus, much like adenomyosis. Statistical correlation was then demonstrated between the severity of endometriosis and the depth of the adenomyosis infiltrates, hence the thickening of the JZE. Stem cells, predominantly found in the JZE were also found in histological sections of leiomyoma, suggested to be the ori...
Source: Current Opinion in Obstetrics and Gynecology - Category: OBGYN Tags: WOMEN'S HEALTH: Edited by Joseph Aquilina Source Type: research
ConclusionEndometrial cancer, specifically type I endometrioid adenocarcinoma and its precursor lesions are strongly associated with unopposed estrogen states such as polycystic ovarian syndrome (PCOS), obesity as well as nulliparity. Patients seeking assisted reproductive technologies make up a subset of these patients and strongly desire to maintain their fertility. Progesterone therapy for select patients may be a safe and effective temporary treatment for endometrial carcinoma and atypical precursor lesions prior to starting IVF-ET. IVF-ET is very effective in treating such patients.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionsAlthough further prospective research on the efficacy of chemotherapy during pregnancy is necessary, survival of patients diagnosed with early stage HL during pregnancy appears not to be statistically different from matched non-pregnant controls, Awareness of complications as preterm delivery and low birth weight is important in this population.Clinical trial identificationNTC00330447.Legal entity responsible for the studyThe authors.FundingEuropean Union ’s Horizon 2020 Research and Innovation Program under grant agreement No 647047 Research Foundation-Flanders (FWO., grant no G070514N) and ESGO (European...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 26 September 2019Source: The Lancet HaematologyAuthor(s): Charlotte Maggen, Daan Dierickx, Pieternella Lugtenburg, Annouschka Laenen, Elyce Cardonick, Roman Smakov, Mar Bellido, Alvaro Cabrera-Garcia, Mina Mhallem Gziri, Michael J Halaska, Petronella B Ottevanger, Kristel Van Calsteren, Andie O'Laughlin, Evgeniya Polushkina, Laura Van Dam, Irit Avivi, Peter Vandenberghe, F J Sherida H Woei-A-Jin, Frédéric Amant, International Network on Cancer, Infertility and PregnancySummaryBackgroundOutcomes for mother and child following a diagnosis of Hodgkin lymphoma during pregnancy a...
Source: The Lancet Haematology - Category: Hematology Source Type: research
d TVF Abstract The human major histocompatibility complex includes a group of non-classical HLA class I genes, HLA-E, -F and -G. While nearly all focus since the discovery of these class Ib molecules have been on basic biochemistry and molecular biology of HLA-G and HLA-E, as well as their expression patterns, functions in immune modulation and during pregnancy, and also possible implications in a range of diseases, in infertility and pregnancy complications, HLA-F has nearly been ignored. However, recent discoveries show that HLA-F can be expressed as both open conformers binding to a number of KIRs on primarily ...
Source: Human Immunology - Category: Allergy & Immunology Authors: Tags: Hum Immunol Source Type: research
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