Wegener's Granulomatosis Mimicking Severe Ulcerative ColitisWegener's Granulomatosis Mimicking Severe Ulcerative Colitis
A 20-year old woman in septic shock presented with a pancolonic, superficial microulceration suggesting ulcerative colitis. What did surgery reveal? Journal of Medical Case Reports
This study reflects the novel IBD treatment targets via the immune system ’s pathway, reporting the latest treatments that regulate the M1/M2 macrophages distribution in a way to favor IBD.
Condition: Inflammatory Bowel Disease Patients Intervention: Sponsor: Assiut University Not yet recruiting
Conditions: Pouchitis; Crhon's Disease Like of the Pouch Intervention: Other: CDED diet Sponsor: Tel-Aviv Sourasky Medical Center Not yet recruiting
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05278
ConclusionsThis study provides estimates of morbidity associated with the rectal stump after subtotal colectomy for IBD. A closed intra-abdominal stump seems to be associated with the highest rate of pelvic abscess/sepsis. Further work in form of an international collaborative project would allow individual patient data analysis and identification of risk factors for complications.
Sepsis is defined as dysregulated host response caused by systemic infection, leading to organ failure. It is a life-threatening condition, often requiring admission to an intensive care unit (ICU). The causative agents and processes involved are multifactorial but are characterized by an overarching inflammatory response, sharing elements in common with severe inflammatory response syndrome (SIRS) of non-infectious origin. Sepsis presents with a range of pathophysiological and genetic features which make clinical differentiation from SIRS very challenging. This may reflect a poor understanding of the key gene inter-activi...
This study was designed to evaluate the effects and mechanisms of obacunone in ameliorating intestinal inflammation in a mouse model of ulcerative colitis (UC). We found that obacunone efficiently alleviated the severity of dextran sulfate sodium (DSS)-induced mouse UC by modulating the abnormal composition of the gut microbiota and attenuating the excessive activation of toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) signaling. The intestinal epithelial barrier was disrupted in DSS colitis mice, which was associated with activation of inflammatory signaling cascades. However, obacunone promoted the expre...
Cannabis, weed, marijuana, pot. It goes by several names, but we all know what it smells like. As weed becomes more mainstream, we on the Not Crazy podcast want to know: Is marijuana really an effective treatment for anxiety? Is it just a coping mechanism? Or a vice? In today’s podcast, Gabe and Jackie look at the research and weigh out the evidence. They also interview Eileen Davidson, a rheumatoid arthritis patient who regularly uses marijuana as a medicine to see what she has to say. What’s your take? Tune in for an open-minded discussion about weed. (Transcript Available Below) SUBSCRIBE &REV...