Controlled Antenatal Thyroid Screening II: effect of treating maternal sub-optimal thyroid function on child behaviour.

CONCLUSIONS: There was no overall association between SGTF and offspring ADHD, ASD or behavior questionnaire scores. However, children of 'over-treated' mothers displayed significantly more ADHD symptoms and behavioral difficulties than normal-GTF. Thyroxine supplementation during pregnancy requires monitoring to avoid over-treatment. PMID: 31665323 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research

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Abstract Over the last decade there has been an increase in the prevalence of autism spectrum disorder (ASD); however, its pathogenic mechanisms remain unclear. To date, no effective drug has been developed to treat the core symptoms of ASD, especially social interaction deficits. Previous studies have mainly focused on the glutamatergic, GABAergic, and serotonergic signaling pathways; however, a growing number of studies have reported abnormalities in the dopaminergic pathway, such as mutations and functional alterations of dopamine-related molecules, in ASD patients. Furthermore, atypical antipsychotic drugs ris...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
To the Editor Preterm birth increases risk of neurodevelopmental delays. High-risk pregnancies for preeclampsia development are at increased risk of preterm birth, the rate of which is dependent on the definitions and screening criteria. Voutetakis et al raise concern of a potential long-term effect of aspirin given to prevent preterm preeclampsia in high-risk pregnancies owing to disruption of cyclooxygenase (COX) 2 and prostaglandin-E2 (PGE2) signaling, potentially affecting prenatal and postnatal brain development with subsequent neurodevelopmental impairments. There are some considerations for this argument. Several pr...
Source: JAMA Pediatrics - Category: Pediatrics Source Type: research
AbstractExposure to gestational stress is implicated in increased risk for neuropsychiatric disorders in offspring. We assessed association between prenatal exposure to a 1-month period of repeated rocket attacks during the 2006 Second Lebanon War in Northern Israel and emergence of childhood neuropsychiatric disorders from birth through 9  years of age. Children born to women who were pregnant during the war (N = 6999) were identified and compared to children in the same district born a year later (N = 7054), whose mothers were not exposed to rocket attacks during pregnancy. Multivariable ...
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
Using acetaminophen during pregnancy may increase the risk of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in children, according to areport published Wednesday inJAMA Psychiatry.For this study, Yuelong Ji, Ph.D., of the Johns Hopkins Bloomberg School of Public Health and colleagues measured the levels of acetaminophen in umbilical cord blood taken after childbirth from 996 women who were part of a study called the Boston Birth Cohort. The study had a 21-year follow-up period.Of the 996 children of these women, 257 were subsequently diagnosed with ADHD, 66 were diagnosed with ASD, 42 w...
Source: Psychiatr News - Category: Psychiatry Tags: ADHD ASD attention-deficit/hyperactivity disorder autism Boston Birth Cohort JAMA Psychiatry pregnancy Yuelong Ji Source Type: research
New research shows that women who took  acetaminophen, best known as Tylenol, at the end of their pregnancies were much more likely to have child with attention-deficit/hyperactivity disorder (ADHD) or autism.
Source: WebMD Health - Category: Consumer Health News Source Type: news
This study contributes to the growing evidence of a link between prenatal exposure to air pollution and autism spectrum disorders, suggesting that prenatal exposure even below current WHO air quality guidelines may increase the risk of autism spectrum disorders. PMID: 31629172 [PubMed - as supplied by publisher]
Source: Environment International - Category: Environmental Health Authors: Tags: Environ Int Source Type: research
Abstract DOHaD (the Developmental Origins of Health and Disease) promises a greater understanding of early development but has left unresolved the balance of risks and benefits to offspring of medication use during pregnancy. Masarwa et al. (Am J Epi 2018;187(8):1817-1827) conducted a meta-analysis of the association between in utero acetaminophen exposure and risks for Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD). A challenge of meta-analyzing results from observational studies is that summary measures of risk do not correspond to welldefined interventions when the individual...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research
Children born by cesarean section may have important differences that affect their neurodevelopment.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Pregnancy and Childbirth Autism Attention Deficit Hyperactivity Disorder Babies and Infants Caesarean Section JAMA Network Open Source Type: news
FRIDAY, Sept. 20, 2019 -- Women who suffer from anemia early in pregnancy are at risk for having a child with autism, attention-deficit/hyperactivity disorder (ADHD) and intellectual disabilities, a study by Swedish researchers suggests. The study...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
WEDNESDAY, Sept. 18, 2019 -- Anemia diagnosed during the first 30 weeks of pregnancy is associated with an increased risk for autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and intellectual disability (ID),...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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