Antitumor properties of triptolide: phenotype regulation of macrophage differentiation.

Antitumor properties of triptolide: phenotype regulation of macrophage differentiation. Cancer Biol Ther. 2019 Oct 30;:1-11 Authors: Li H, Li L, Mei H, Pan G, Wang X, Huang X, Wang T, Jiang Z, Zhang L, Sun L Abstract Tumor-associated macrophages (TAMs), which generally exhibit an M2-like phenotype, play a critical role in tumor development. Triptolide exerts a unique bioactive spectrum of anticancer activities. The aim of this study was to determine whether triptolide has any effect on the activation of TAMs and the production of tumor-promoting mediators. ICR-1 mice with azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colon tumors and BALB/c mice co-inoculated with 4T1 cells and M2-polarized RAW264.7 cells were used to examine whether the inhibitory effect of triptolide on tumor progression was mediated by the targeting of TAMs. Real-time PCR, Western blot, immunofluorescence staining, and flow cytometry assays were performed to determine the expression of cell surface markers and cytokine production. The results showed that triptolide inhibited macrophage differentiation toward the M2 phenotype and abolished M2 macrophage-mediated tumor progression. Furthermore, triptolide inhibited the expression of M2 markers, such as CD206, Arginase 1, and CD204, and inhibited the secretion of anti-inflammatory cytokines. Thus our study indicated that triptolide selectively inhibited the functions of M2-polarized macrophages and TAMs, and this inhibitory effec...
Source: Cancer Biology and Therapy - Category: Cancer & Oncology Authors: Tags: Cancer Biol Ther Source Type: research

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Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
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Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
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Source: Breast Cancer - Category: Cancer & Oncology Authors: Tags: Breast Cancer Source Type: research
Some of the most common symptoms experienced by cancer patients are memory problems, difficulties with multitasking, and reduced attention and concentration. Historically, cancer patients with these symptoms were often diagnosed with depression. Research over the past decade has revealed that many cancer patients experience such symptoms as a consequence of specific damage to the brain caused by either their tumor or their treatment. While radiation to the brain has long been linked to causing cognitive difficulties, the effects of chemotherapy on brain structure and function have only recently been discovered. We now know...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Brain and cognitive health Cancer Memory Radiation Source Type: blogs
Publication date: Available online 18 November 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Juan Liao, Siyu Peng, Mei Long, Yaya Zhang, Huaming Yang, Yi Zhang, Jing HuangAbstractNatural halloysite clay nanotubes (halloysite nanotubes, HNTs) are potentially used in colon cancer therapy owing to their excellent physicochemical properties. However, the size-dependent interaction between HNTs and colon cancer cells is still an unresolved challenge. Herein, we analyzed the interfacial interactions between HNTs and colon cancer cells, and evaluated the size-dependent biological effects o...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
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Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research
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Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
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Source: Cell Reports - Category: Cytology Source Type: research
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