DiseaSE: A Biomedical Text Analytics System for Disease Symptom Extraction and Characterization

Publication date: Available online 31 October 2019Source: Journal of Biomedical InformaticsAuthor(s): Muhammad Abulaish, Md. Aslam Parwez, JahiruddinAbstractDue to increasing volume and unstructured nature of the scientific literatures in biomedical domain, most of the information embedded within them remain untapped. This paper presents a biomedical text analytics system, DiseaSE (Disease Symptom Extraction), to identify and extract disease symptoms and their associations from biomedical text documents retrieved from the PubMed database. It implements various NLP and information extraction techniques to convert text documents into record-size information components that are represented as semantic triples and processed using TextRank and other ranking techniques to identify feasible disease symptoms. Eight different diseases, including dengue, malaria, cholera, diarrhoea, influenza, meningitis, leishmaniasis, and kala-azar are considered for experimental evaluation of the proposed DiseaSE system. On analysis, we found that the DiseaSE system is able to identify new symptoms that are even not catalogued on standard websites such as Center for Disease Control (CDC), World Health Organization (WHO), and National Health Survey (NHS). The proposed DiseaSE system also aims to compile generic associations between a disease and its symptoms, and presents a graph-theoretic analysis and visualization scheme to characterize disease at different levels of granularity. The identified dis...
Source: Journal of Biomedical Informatics - Category: Information Technology Source Type: research

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Publication date: Available online 11 December 2019Source: The Lancet Global HealthAuthor(s): Adam Wagstaff, Sven NeelsenSummaryBackgroundThe goal of universal health coverage (UHC) requires that everyone receive needed health services, and that families who get needed services do not suffer undue financial hardship. Tracking progress towards UHC requires measurement of both these dimensions, and a way of trading them off against one another.MethodsWe measured service coverage by a weighted geometric average of four prevention indicators (antenatal care, full immunisation, and screening for breast and cervical cancers) and...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
We present the case of a patient with a second-degree open dislocated ankle fracture and a complex wound situation as well as fever in the postoperative course. The man, originally from Nigeria, spent his annual holidays in a rural area of ​​the country, where he sustained a right-sided open dislocation fracture of his ankle in a car accident. After initial rudimentary care in Nigeria, the patient traveled back to Switzerland on his own, where he has been living for the past ten years. Back in Zurich he presented himself to our Department for Emergency Medicine. He was admitted to our Trauma Unit and received surgical ...
Source: Praxis - Category: General Medicine Authors: Tags: Praxis (Bern 1994) Source Type: research
THURSDAY, Dec. 12, 2019 -- Few child care center directors report having an influenza vaccine requirement for children and adult caregivers, according to a study published online Dec. 12 in the Journal of the Pediatric Infectious Diseases...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Conclusion: Our results suggest that linezolid as an alternative to vancomycin for the treatment of PNSI caused by MRS with a high rate of efficacy. PMID: 31819809 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
J. L. Abbate et al.
Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research
(Pediatric Infectious Diseases Society) Influenza can be especially dangerous for children, who are at greater risk for serious complications from the illness, including hospitalization and even death. Yet child care centers in the US rarely require children or the adults who care for them to be vaccinated against flu, according to a new study published in the Journal of the Pediatric Infectious Diseases Society.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 10 December 2019Source: The LancetAuthor(s): Maria-Victoria Mateos, Michele Cavo, Joan Blade, Meletios A Dimopoulos, Kenshi Suzuki, Andrzej Jakubowiak, Stefan Knop, Chantal Doyen, Paulo Lucio, Zsolt Nagy, Ludek Pour, Mark Cook, Sebastian Grosicki, Andre Crepaldi, Anna Marina Liberati, Philip Campbell, Tatiana Shelekhova, Sung-Soo Yoon, Genadi Iosava, Tomoaki FujisakiSummaryBackgroundStandard-of-care treatment for patients with newly diagnosed multiple myeloma includes combination therapies for patients who are not eligible for autologous stem-cell transplantation. At the primary analysis ...
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: Available online 10 December 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Alina A. Okhina, Artem D. Rogachev, Olga I. Yarovaya, Mikhail V. Khvostov, Tatyana G. Tolstikova, Andrey G. Pokrovsky, Veniamin A. Khazanov, Nariman F. SalakhutdinovAbstractA method of quantitative determination of camphecene, a new anti-influenza agent, in rat blood plasma based on LC-MS/MS was developed, validated and used to study the distribution of the agent between blood cells and blood plasma. The method was validated according to FDA and EMA recommendations in terms of selectivity, linearity, accur...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
ConclusionsThe SE damaged the cell membrane, with the cytoplasm flowing out, disturbed the synthesis of total protein and phosphorus metabolism, and ultimately killed the bacteria.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
In this study, we generate a mouse strain capable of reporting IFN-signaling activated by all three types of IFNs and investigate the spatio-temporal dynamics and identity of IFN-responding cells following IFN injection and influenza virus infection. Despite ubiquitous expression of IFN receptors, cellular responses to IFNs are highly heterogenous in vivo and are determined by anatomical site, cell type, cellular preference to individual IFNs, and activation status. Unexpectedly, type I and II pneumocytes, the primary target of influenza infection, exhibit striking differences in the strength and temporal dynamics of ...
Source: Cell Reports - Category: Cytology Source Type: research
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