Sericin Grafted Multifunctional Curcumin Loaded Fluorinated Graphene Oxide Nanomedicines with Charge Switching Properties for Effective Cancer Cell Targeting

Publication date: Available online 31 October 2019Source: International Journal of PharmaceuticsAuthor(s): Mohammadjavad Jahanshahi, Elaheh Kowsari, Vahid Haddadi-Asl, Mehdi Khoobi, Jong Hyun Lee, Firoz Babu Kadumudi, Sepehr Talebian, Nazila Kamaly, Mehdi MehraliAbstractFluorinated graphene has recently gained much attention for cancer drug delivery, owing to its peculiar properties including high electronegativity difference, magnetic resonance imaging contrast agent, and the photothermal effect. However, the hydrophobic nature of fluorinated graphene greatly hinders its application as a biological material. Herein, a novel green method is reported for synthesis of a pH-sensitive charge-reversal and water-soluble fluorinated graphene oxide, modified with polyethyleneimine anchored to sericin-polypeptide (FPS). This nanocarrier was further loaded with curcumin (Cur), and characterized as a nanocarrier for anti-cancer drug delivery. The synthesized nanocarriers contain two different pH-sensitive amide linkages, which are negatively charged in blood pH (≈7.4) and can prolong circulation times. The amide linkages undergo hydrolysis once they reach the mildly acidic condition (pH≈6.5, corresponding to tumor extracellular matrix), and subsequently once reached the lower acidic condition (pH≈5.5, corresponded to endo/lysosomes microenvironment), the FPS charge can be switched to positive (≈+28 mV), which aids the nuclear release. This nanocarrier was designe...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

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Conclusion: 3T3-L1 cells, treated with LPV/RTV, show altered lipid content due to increased miRNA-218 levels, which affects lipin-1 mRNA. Moreover, increased miRNA-218 levels were inversely correlated with changes in GLUT-4 expression, which suggests a role for miRNA-218 in mediating the insulin resistance consequent to cART. Introduction Metabolic syndrome is a serious consequence of combined Antiretroviral Therapy (cART). HIV-associated metabolic syndrome is often accompanied by lipodystrophy (LS), the redistribution of body fat with loss of subcutaneous adipose tissue in face, limbs and buttocks, concomitant wit...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In this study, β2∗ nAChR-containing receptors and lynx1 were identified using pull down studies from the mouse brain (Nissen et al., 2018), while ws-lynx1, SLURP-1 and SLURP-2 has been successfully mixed with human brain tissue to pull down multiple nAChR subtypes (Lyukmanova et al., 2016a,b; Thomsen et al., 2016). To support the in vivo interaction studies, a lynx1KO phenotype was ameliorated by crossing these mice into mutant mice null for α7 and β2 nAChR genes (Miwa et al., 2006). These in vivo studies provide an important biological context for the interactions observed within in vitro systems. ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
AbstractPurposeThe prevalence of non-AIDS-related malignancies is on the rise among people aging with HIV population, but the evidence on healthy behaviors including cancer screening practices in this population subgroup is extremely limited. Therefore, we investigated the prevalence of healthy behaviors and sex-specific cancer screening among persons living with HIV, by sex and time since HIV diagnosis.MethodsWe included 517 persons living with HIV from the Florida Cohort. Data were obtained from the baseline and follow-up questionnaires, electronic medical records, and Enhanced HIV/AIDS Reporting System. The prevalence o...
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
Publication date: Available online 21 September 2018Source: The Lancet HIVAuthor(s): Nancy A Hessol, Hannah Whittemore, Eric Vittinghoff, Ling C Hsu, Danning Ma, Susan Scheer, Sandra K SchwarczSummaryBackgroundCancer survivors are at increased risk for subsequent primary cancers. People living with HIV are at increased risk for AIDS-defining and non-AIDS-defining cancers, but little is known about their risk of first versus second primary cancers. We identified first and second primary cancers that occurred in above population expected numbers among people diagnosed with HIV in San Francisco, and compared first and second ...
Source: The Lancet HIV - Category: Infectious Diseases Source Type: research
Conclusion: The cancer burden among PLWH is projected to shift, with prostate and lung cancer expected to emerge as the most common types by 2030. Cancer will remain an important comorbid condition, and expanded access to HIV therapies and cancer prevention, screening, and treatment is needed. Primary Funding Source: National Cancer Institute. PMID: 29801099 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
On May 13, 2016, the U.S. Department of Health and Human Services Office for Civil Rights (HHS OCR) issued a historic new rule that codifies nationwide nondiscrimination protections for lesbian, gay, bisexual, and transgender (LGBT) people in health facilities, programs, and activities receiving federal funding. This rule confirms that Affordable Care Act Section 1557 prohibits discrimination against LGBT people in health insurance coverage and health care. Key provisions of the final rule that relate specifically to LGBT people include: Interpreting Section 1557’s sex nondiscrimination protections to include explic...
Source: Health Affairs Blog - Category: Health Management Authors: Tags: Costs and Spending Equity and Disparities Following the ACA Insurance and Coverage Medicaid and CHIP Public Health Quality HHS OCR LGBT issues section 1557 transgender rights Source Type: blogs
ConclusionDeveloping and implementing comprehensive context‐relevant health literacy interventions in community settings are urgently needed. Copyright © 2016 John Wiley &Sons, Ltd.
Source: Psycho-Oncology - Category: Cancer & Oncology Authors: Tags: Paper Source Type: research
SPECIAL FROM Cayenne, jalapeno, habanero, chili—it seems like there are a million different kinds of hot peppers you can buy. And not only are they a great way to add flavor to your recipes, research shows that they may have a surprisingly positive effect on your health. Hot peppers, like jalapeños and chills, are rich in a component called capsaicin. "What we now know about capsaicin is that it has many benefits in terms of adding to the resistance to disease," says Cary Present, M.D., a medical oncologist at City of Hope hospitalin California and author ofSurviving American Medicine. "Cap...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
In light of Caitlyn Jenner’s 2015 Arthur Ashe Courage Award acceptance speech at the ESPYs last night we are running the post below for TBT. It first ran on Disruptive Women in June 2014.  Lesbian, Gay, Bisexual and Transgender (LGBT) individuals are becoming increasingly visible in our society. Unfortunately, they are subjected to discrimination and stigma similar to other marginalized groups such as racial and ethnic minorities and people with disabilities. The current political and social context and unique health care needs, impact the health of LGBT individuals, resulting in health disparities (poorer healt...
Source: Disruptive Women in Health Care - Category: Consumer Health News Authors: Tags: Advocacy TBT Source Type: blogs
Conclusions: Our findings suggest that AIDS-defining malignancies and other malignancies are likely to remain significant public health burdens in sub-Saharan Africa even as ART availability increases.
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - Category: Infectious Diseases Tags: Epidemiology and Prevention Source Type: research
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