Neural correlates of reward magnitude and delay during a probabilistic delay discounting task in alcohol use disorder

ConclusionsThe results of this study extend previous findings that alcohol use disorder is associated with differences in activation during an immediate or delayed choice by delineating activation associated with the parameters of impulsive choice.
Source: Psychopharmacology - Category: Psychiatry Source Type: research

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Conclusions: In this report, we describe a rare case of ALL with HCC, located in the left subphrenic area, especially which was supplied by the branch of left hepatic artery has rarely been described. The clinical presentation, radiological features are described in the literature.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Abstract BACKGROUND: While many adolescents exhibit risky behavior, teenagers with a family history (FH+) of an alcohol use disorder (AUD) are at a heightened risk for earlier initiation of alcohol use, a more rapid escalation in frequency and quantity of alcohol consumption and developing a subsequent AUD in comparison to youth without such family history (FH-). Neuroanatomically, developmentally normative risk-taking behavior parallels an imbalance between more protracted development of the pre-frontal cortex (PFC) and earlier development of limbic regions. Magnetic resonance imaging (MRI) derived volumetric pro...
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Tags: Alcohol Clin Exp Res Source Type: research
Conclusion: Converging evidence suggests that CD38 rs3796863 genotype may increase DA-related reward response and alcohol consumption. PMID: 31365285 [PubMed - as supplied by publisher]
Source: The American Journal of Drug and Alcohol Abuse - Category: Addiction Authors: Tags: Am J Drug Alcohol Abuse Source Type: research
ConclusionsThis study offers preliminary evidence of alcohol-related increases in Glx/Cr, Cho/Cr and GSH/Cr on the descending limb of blood alcohol concentration. Findings add novel information to previous research on neurometabolic changes at peak blood alcohol in healthy individuals and during withdrawal in individuals with alcohol use disorder.
Source: Alcohol and Alcoholism - Category: Addiction Source Type: research
Conclusions: This study found similar associations between smoking and vascular brain injury among American Indians, as seen in other populations. In particular, these findings support the role of smoking as a key correlate for cerebral atrophy.Neuroepidemiology
Source: Neuroepidemiology - Category: Epidemiology Source Type: research
Altered activity within reward-related neural regions, including the ventral striatum (VS) and medial prefrontal cortex (mPFC), is associated with concurrent problematic substance use. The aims of the present study were to (a) identify patterns of reward-related neural activity that prospectively predict changes in alcohol use two years after magnetic resonance imaging (MRI) scanning in a sample of adolescents, and (b) examine whether these patterns differ by sex. We also tested whether depression symptoms or impulsivity mediated associations between neural activity and future alcohol use.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: New Research Source Type: research
CONCLUSIONS: The severity of WMHs at baseline was associated with cognitive decline in the non-demented elderly over time. Interventions on WMH lesions may offer some benefits for cognitive deterioration. PMID: 31133080 [PubMed - as supplied by publisher]
Source: The Canadian Journal of Neurological Sciences - Category: Neurology Authors: Tags: Can J Neurol Sci Source Type: research
AbstractBackgroundMorbid obesity is a worldwide epidemic and is increasingly treated by bariatric surgery. Fatty liver is a common finding; almost half of all patients with non-alcoholic steatohepatitis develop steatohepatitis. Bariatric surgery improves steatohepatitis documented by liver biopsy and single voxel magnetic resonance imaging (MRI) techniques.ObjectiveTo investigate changes before and after bariatric surgery using whole organ MRI quantification of liver, visceral, and subcutaneous fat.SettingUniversity of Basel Hospital and St. Clara Research Ltd, Basel, Switzerland.MethodsSixteen morbidly obese patients were...
Source: Obesity Surgery - Category: Surgery Source Type: research
Junjie Bu1,2, Ru Ma2, Chuan Fan3,4, Shinan Sun5, Yan Cheng3, Yi Piao3, Pengyu Zhang2, Chialun Liu2 and Xiaochu Zhang1,2,3,5*1Hefei Medical Research Center on Alcohol Addiction, Anhui Mental Health Center, Hefei, China2Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science &Technology of China, Hefei, China3School of Humanities &Social Science, University of Science &Technology of China, Hefei, China4Department of Medical Psychology, the First Affiliated Hospital of Anhui Medical University, Hefei, China5Academy of Psychology and Behavior, Tianjin Nor...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusion: Patients with isolated thalamic atrophy were at a higher risk for not reaching 2-year NEDA-3 and for EDSS increase than patients with no identified brain atrophy. The groups were clinically indistinguishable. A single measurement of thalamic and whole brain atrophy could help identify patients needing most effective therapies from early on. Introduction The quantification of brain atrophy by MRI has become an increasingly important part of evaluating neurodegeneration in MS (1, 2). Atrophy measures can reflect the damage on the central nervous system (CNS) caused by the pathological processes of the dis...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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