Angiopoietin-1 aggravates atherosclerosis by inhibiting cholesterol efflux and promoting inflammatory response

ConclusionAng-1 has an adverse effect on cholesterol efflux by decreasing the expression of ABCA1 and ABCG1 via Tie2/TFE3/LXRα pathway, thereby promoting inflammation and accelerating atherosclerosis progression.

Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - October 31, 2019 Category: Lipidology Source Type: research