First magnetic particle imaging angiography in human-sized organs by employing a multimodal ex vivo pig kidney perfusion system
Objective : Magnetic particle imaging (MPI) is a new, fast 3D imaging technique, which is considered
promising for angiographies. As available MPI scanners suffer from restricted spatial resolution and
are mostly constructed for small animal imaging, no vessels within one organ have been depicted by
MPI, yet. The purpose of this study was to develop an ex vivo organ perfusion system to display
vessels within one organ of human size by MPI and to compare the results to an established 3D
imaging technique. Approach : An ex vivo porcine kidney perfusion system compatible with digital
subtraction angiography (DSA), magnetic resonance tomography and MPI was developed. DSA was used to
exemplarily prove intact vessel structures under ex vivo perfusion in two organs. Perfusion in nine
organs was displayed by the 3D imaging techniques magnetic resonance angiography (MRA) and MPI
angiography. All visible vessels in MRA and MPI were counted and their numbe...
Source: Physiological Measurement - Category: Physiology Authors: I Molwitz, H Ittrich, T Knopp, T Mummert, J Salamon, C Jung, G Adam and M G Kaul Source Type: research