Changes in electrolyte concentrations alter the impedance during ischemia-reperfusion injury in rat brain

In this study, changes in the bio-impedance spectroscopy using a two-electrode method
with varying frequencies from 100 to 35  kHz have been assessed in a model of global cerebral
ischemia in anesthetized rats during normal, occlusion and reperfusion conditions. Global cerebral
ischemia was induced by bilateral common carotid artery occlusion for 40  min following 40 min of
reperfusion. The concentration of sodium, potassium, calcium and chloride ions in the whole rat
brain was determined by electrolyte analyzer. For the interpretation of in vivo results, changes in
electrical impedance with varying concentrations of sodium, potassium and calcium ions in artificial
cerebrospinal fluid (aCSF) were also observed using the bio-impedance spectroscopy method. ...

Source: Physiological Measurement - October 29, 2019 Category: Physiology Authors: Gaurav Kumar, Uvanesh Kasiviswanathan, Sumedha Mukherjee, Sanjeev Kumar Mahto, Neeraj Sharma and Ranjana Patnaik Source Type: research