Characterization of 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidases from Borrelia burgdorferi: Antibiotic targets for Lyme disease

ConclusionB. burgdorferi is unusual in that it expresses three distinct MTNs (cytoplasmic, membrane bound, and secreted) that are effectively inactivated by nucleoside analogs.General significanceThe Borrelia MTNs appear to be promising targets for developing new antibiotics to treat Lyme disease.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research

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Source: Epidemiology - Category: Epidemiology Tags: Psychosocial Epidemiology Source Type: research
No abstract available
Source: Epidemiology - Category: Epidemiology Tags: Psychosocial Epidemiology Source Type: research
Conclusions: To our knowledge, this was the first individual-level US-based study with repeated union-membership measurements to analyze the union–mortality relationship. We estimated a protective union–mortality association, but found little evidence declining union density has exacerbated mortality inequities; importantly, we did not incorporate contextual-level effects. See video abstract at, http://links.lww.com/EDE/B839.
Source: Epidemiology - Category: Epidemiology Tags: Psychosocial Epidemiology Source Type: research
Conclusions: Comprehensive handheld bans were associated with fewer driver fatalities.
Source: Epidemiology - Category: Epidemiology Tags: Psychosocial Epidemiology Source Type: research
Ticks are obligate hematophagous ectoparasites. They are important vectors for many pathogens, of both medical and veterinary importance. Antibiotic residues in animal food are known, but very little is known about the effects of antibiotic residues in animals on the microbiome diversity of ticks and tick-borne pathogen transmission. We used a Haemaphysalis longicornis–infested mouse model to evaluate the effect of antibiotic usage on tick microbiome. Nymphal ticks were fed on an antibiotic cocktail-treated or water control mice. Adult ticks molted from nymphs fed on the antibiotic cocktail-treated mouse had a dysbio...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
An attorney for the former president objects to the Treasury Department’s intention to turn over tax records to a congressional committee.
Source: Reuters: Health - Category: Consumer Health News Source Type: news
Abstract Borrelia burgdorferi is the causative agent of Lyme disease, the leading tick-borne illness in the United States. However, due to, in part, to the significant number of proteins of unknown function encoded across the complex fragmented genome, the molecular mechanisms of B. burgdorferi infection remain largely undefined. Previous work identified the virulence determinant gene, bbk13, which is critical for B. burgdorferi's ability to establish a productive disseminated infection. BBK13 is an immunogenic, non-surface exposed protein of unknown function predicted to harbor an N-terminal transmembra...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
Charlotte Mason1, Xiaoyan Liu2, Spoorthy Prabhudeva1 and Zhiming Ouyang1* 1Department of Molecular Medicine, University of South Florida, Tampa, FL, United States 2Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, United States BosR, a Fur family member, is essential for the pathogenesis of the Lyme disease pathogen, Borrelia burgdorferi. Unlike typical Fur proteins in which DNA binding represses gene expression, binding of BosR to the rpoS promoter directly activates rpoS transcription in B. burgdorferi. However, virtually nothing is known concerning potential structural fea...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
In this study, bird species migrating through Bulgaria were investigated as carriers of zoonotic pathogens. In total, 706 birds belonging to 46 species were checked for the presence of various bacterial pathogens (Campylobacter, Yersin ia, Salmonella, Listeria, Escherichia coli, Staphylococcus aureus, Francisella tularensis, Coxiella burnetii, Borrelia burgdorferi, and Brucella spp.). From 673 birds we investigated fecal samples, from the remaining 33, blood samples. We detected Campylobacter 16S rDNA gene in 1.3% of birds, but no ne were of pathogenic Campylobacter jejuni and Campylobacter coli species. Escherichia coli 1...
Source: Canadian Journal of Microbiology - Category: Microbiology Authors: Source Type: research
Answer:Borreliaspp., relapsing fever group. Molecular studies are needed to definitively identify the causative agent. However, knowing the exposure history of the patient also helps narrow the differential. In this case, we later found out that the patient is from the northwestern part of North America, and therefore this is most likelyBorrelia hermsii,one of the tick-borne relapsing feverBorreliaspecies.The other tick-borneBorreliain North America areB. parkeriiandB. turicatae.These species are transmitted through the bite of a soft-bodied tick in the genusOrnithodoros,and are usually associated with exposure to'rustic's...
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
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