Characterization of 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidases from Borrelia burgdorferi: Antibiotic targets for Lyme disease

ConclusionB. burgdorferi is unusual in that it expresses three distinct MTNs (cytoplasmic, membrane bound, and secreted) that are effectively inactivated by nucleoside analogs.General significanceThe Borrelia MTNs appear to be promising targets for developing new antibiotics to treat Lyme disease.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research

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Analyst, 2020, Accepted Manuscript DOI: 10.1039/D0AN01306D, PaperNatkrittaya Saengsawang, Toon Ruang-areerate, Piyanate Kesakomol, Thunyapit Thunyapit , Mathirut Mungthin, Wijitar Dungchai The highly sensitive and selective determination ofEscherichia coli(E. coli) in urine using SYBRTM Safe loop-mediated Isothermal Amplification (LAMP) method with a distance-based paper device was developed. The new... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
Authors: Diomidous M, Magdalinou A, Mantas J Abstract This chapter aims at providing the student with a general overview of the Health Organization Development and Design basic concepts. More precisely, this chapter outlines the origins and the future of Health services planning and development and the structure of health organizations. The typology of different international healthcare systems implemented in United Kingdom, United States of America, Greece, Serbia and Germany is also presented. PMID: 32990663 [PubMed - in process]
Source: Studies in Health Technology and Informatics - Category: Information Technology Tags: Stud Health Technol Inform Source Type: research
Publication date: December 2020Source: Journal of Functional Foods, Volume 75Author(s): Yawei Chen, Yiting Cao, Weizhen Kong, Yiying Shi, Wanqing Cheng
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
The C.D.C. director wanted a “no sail” order extended until February, a policy that would have upset the tourism industry in the crucial swing state of Florida.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Coronavirus (2019-nCoV) Cruises Redfield, Robert R Centers for Disease Control and Prevention Florida Trump, Donald J United States Politics and Government Lobbying and Lobbyists Coronavirus Reopenings Travel Warnings Source Type: news
CONCLUSION: The multi-epitope vaccine is a suitable stimulator for immune system and would be a candidate for experimental research. Recent patents describing numerous inventions related to the clinical facets of vaccine peptide against human infectious disease. PMID: 32990553 [PubMed - as supplied by publisher]
Source: Current Aging Science - Category: Geriatrics Tags: Curr Aging Sci Source Type: research
The president said at Tuesday’s debate that he lowered insulin prices. That’s not true — and, for some, the drug’s expense is a fatal barrier.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news
Authors: Etzioni A Abstract Micro decisions, made by individuals, during a health crisis in which healthcare resources are particularly in short supply, should not be based only on the age of the patients. Ameliorate  care is only appreciated  when the patient has a limited time to live, whatever their age. Macro decisions concern public policy. We must decide now who will pay for the vaccines, who will get them before others, whether minorities should be granted priority, and whether the United States should join a global distribution system. PMID: 32991328 [PubMed - as supplied by publisher]
Source: Journal of Clinical Ethics - Category: Medical Ethics Tags: J Clin Ethics Source Type: research
Charlotte Mason1, Xiaoyan Liu2, Spoorthy Prabhudeva1 and Zhiming Ouyang1* 1Department of Molecular Medicine, University of South Florida, Tampa, FL, United States 2Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, United States BosR, a Fur family member, is essential for the pathogenesis of the Lyme disease pathogen, Borrelia burgdorferi. Unlike typical Fur proteins in which DNA binding represses gene expression, binding of BosR to the rpoS promoter directly activates rpoS transcription in B. burgdorferi. However, virtually nothing is known concerning potential structural fea...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
In this study, bird species migrating through Bulgaria were investigated as carriers of zoonotic pathogens. In total, 706 birds belonging to 46 species were checked for the presence of various bacterial pathogens (Campylobacter, Yersin ia, Salmonella, Listeria, Escherichia coli, Staphylococcus aureus, Francisella tularensis, Coxiella burnetii, Borrelia burgdorferi, and Brucella spp.). From 673 birds we investigated fecal samples, from the remaining 33, blood samples. We detected Campylobacter 16S rDNA gene in 1.3% of birds, but no ne were of pathogenic Campylobacter jejuni and Campylobacter coli species. Escherichia coli 1...
Source: Canadian Journal of Microbiology - Category: Microbiology Authors: Source Type: research
Answer:Borreliaspp., relapsing fever group. Molecular studies are needed to definitively identify the causative agent. However, knowing the exposure history of the patient also helps narrow the differential. In this case, we later found out that the patient is from the northwestern part of North America, and therefore this is most likelyBorrelia hermsii,one of the tick-borne relapsing feverBorreliaspecies.The other tick-borneBorreliain North America areB. parkeriiandB. turicatae.These species are transmitted through the bite of a soft-bodied tick in the genusOrnithodoros,and are usually associated with exposure to'rustic's...
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
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