Ribosome recycling in mRNA translation, quality control, and homeostasis.

Ribosome recycling in mRNA translation, quality control, and homeostasis.
Biol Chem. 2019 Oct 01;:
Authors: Nürenberg-Goloub E, Tampé R
Abstract
Protein biosynthesis is a conserved process, essential for life. Ongoing research for four decades has revealed the structural basis and mechanistic details of most protein biosynthesis steps. Numerous pathways and their regulation have recently been added to the translation system describing protein quality control and mRNA surveillance, ribosome-associated protein folding and post-translational modification as well as human disorders associated with mRNA and ribosome homeostasis. Thus, translation constitutes a key regulatory process placing the ribosome as a central hub at the crossover of numerous cellular pathways. Here, we describe the role of ribosome recycling by ABCE1 as a crucial regulatory step controlling the biogenesis of functional proteins and the degradation of aberrant nascent chains in quality control processes.
PMID: 31665102 [PubMed - as supplied by publisher]

Source: Biological Chemistry - October 31, 2019 Category: Chemistry Tags: Biol Chem Source Type: research