Lyme disease symptoms: The major warning sign that could signal you have the condition

LYME disease is an infectious disease caused by a bacterium named Borrelia, spread by ticks found in the woods. It can easily be caught and if a person experiences this one particular sign it could be a major warning that you may be at risk of having the disease. What is it?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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This study aimed to asse...
Source: Acta Veterinaria Scandinavica - Category: Veterinary Research Authors: Tags: Brief communication Source Type: research
Publication date: Available online 24 July 2020Source: Ticks and Tick-borne DiseasesAuthor(s): Annetta Zintl, Taher Zaid, Fiona McKiernan, Amalia Naranjo-Lucena, Jeremy Gray, Sorcha Brosnan, John Browne, Jack O’Connor, John Mee, Barbara Good, Emma L. Gillingham, Alexander G.C. Vaux, Jolyon Medlock
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
We report the results of gene expression profiling via RNA-sequencing of primary human choroid plexus epithelial cells in vitro that were infected with Borrelia burgdorferi, the causative agent of Lyme disease. Epithelial cells were cultured with B. burgdorferi for 48 hours prior to RNA isolation. Following high-throughput sequencing via Illumina HiSeq 4000, a total of 258 differentially expressed genes were identified. Subsequent data analysis indicates an inflammatory and immune response generated by the epithelial cells following infection, marked by chemotactic cytokines and interferon stimulated genes. Several genes a...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
We examined the effect of a positive serostatus at baseline for selected pathogens associated with chronic infections (Helicobacter pylori,Borrelia burgdorferi sensulato,Toxoplasma gondii, cytomegalovirus, Epstein-Barr virus, herpes simplex virus 1/2, and human herpesvirus 6) on all-cause mortality with multivariable parametric survival models. We found a reduced survival time in individuals with a positive serostatus forHelicobacter pylori (accelerated failure time (AFT) − 15.92, 95% CI − 29.96; − 1.88), cytomegalovirus (AFT − 22.81, 95% CI − 36.41; −&...
Source: AGE - Category: Geriatrics Source Type: research
Publication date: Available online 5 July 2020Source: The Veterinary JournalAuthor(s): A.L. Hatke, D.R. Green, K. Stasiak, R.T. Marconi
Source: The Veterinary Journal - Category: Veterinary Research Source Type: research
Vector-Borne and Zoonotic Diseases, Ahead of Print.
Source: Vector-Borne and Zoonotic Diseases - Category: Infectious Diseases Authors: Source Type: research
Compared to the standard two-tiered testing (STTT) algorithm for Lyme disease serology using an enzyme immunoassay (EIA) followed by Western blotting, data from the United States suggest that a modified two-tiered testing (MTTT) algorithm employing two EIAs has improved sensitivity to detect early localized Borrelia burgdorferi infections without compromising specificity. From 2011 to 2014, in the Canadian province of Nova Scotia, where Lyme disease is hyperendemic, sera submitted for Lyme disease testing were subjected to a whole-cell EIA, followed by C6 EIA and subsequently IgM and/or IgG immunoblots on sera with EIA-pos...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Immunoassays Source Type: research
A series of cases in the Northeast of the US during 2013 –2015 described a new Borrelia species, Borrelia miyamotoi, which is transmitted by the same tick species that transmits Lyme disease and causes a relapsing...
Source: Annals of Clinical Microbiology and Antimicrobials - Category: Microbiology Authors: Tags: Short report Source Type: research
Mitochondria, chloroplasts and several species of bacteria have outer membrane proteins (OMPs) that perform many essential biological functions. The β -barrel assembly machinery (BAM) complex is one of the OMPs of Borrelia burgdorferi, the pathogenic spirochete that causes Lyme disease, and its BamA component (BbBamA) includes a C-terminal β -barrel domain and five N-terminal periplasmic polypeptide-transport-associated (POTRA) domains, which together perform a central transport function. In the current work, the production, crystallization and X-ray analysis of the three N-terminal POTRA domains of BbBamA (BbBam...
Source: Acta Crystallographica Section F - Category: Biochemistry Authors: Tags: Borrelia burgdorferi BbBamA-POTRA P1 – P3 crystallization research communications Source Type: research
Lyme disease (LD) is an increasing public health problem. Current laboratory testing is insensitive in early infection, the stage at which appropriate treatment is most effective in preventing disease sequelae. The Lyme Disease Biobank (LDB) collects samples from individuals with symptoms consistent with early LD presenting with or without erythema migrans (EM) or an annular, expanding skin lesion and uninfected individuals from areas of endemicity. Samples were collected from 550 participants (298 cases and 252 controls) according to institutional review board-approved protocols and shipped to a centralized biorepository....
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Immunoassays Source Type: research
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