Structure of the Fanconi anaemia monoubiquitin ligase complex

Nature, Published online: 30 October 2019; doi:10.1038/s41586-019-1703-4The structure of the multiprotein Fanconi anaemia core complex, determined using cryo-electron microscopy and mass spectrometry, shows that the complex adopts an extended asymmetric structure and highlights the structural and functional asymmetry of the RING finger domains.

Source: Nature AOP - October 29, 2019 Category: Research Authors: Shabih Shakeel Eeson Rajendra Pablo Alc ón Francis O ’Reilly Dror S. Chorev Sarah Maslen Gianluca Degliesposti Christopher J. Russo Shaoda He Chris H. Hill J. Mark Skehel Sjors H. W. Scheres Ketan J. Patel Juri Rappsilber Carol V. Robinson Lori A. Pass Source Type: research