Intrathecal Interferon Benefits Devastating Post-Measles Syndrome Intrathecal Interferon Benefits Devastating Post-Measles Syndrome

Intrathecal interferon improves several measures of neurologic disability in devastating post-measles subacute sclerosing panencephalitis, a study shows. Most of the patients had not been immunized.Medscape Medical News
Source: Medscape Infectious Diseases Headlines - Category: Infectious Diseases Tags: Neurology & Neurosurgery News Source Type: news

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Subacute sclerosing panencephalitis (SSPE) is a rare neurodegenerative disorder caused by a persistent infection with aberrant measles virus. Indoleamine-2, 3-dioxygenase (IDO) initiates the increased production of kynurenine pathway (KP) metabolites quinolinic acid (QUIN), which has an excitotoxic effect for neurons. We measured serum IDO activity and cerebrospinal fluid (CSF) levels of QUIN. The CSF QUIN levels were significantly higher in SSPE patients than in controls, and increased according as neurological disability in a patient studied.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Source Type: research
(This post has been updated with relevant recent information.) The United States was declared free from ongoing measles transmission in 2000. But we may be at risk for joining the UK Greece, Albania, and the Czech Republic, four countries recently stripped of measles elimination status by the World Health Organization. Since the beginning of 2019, more than 1,234 measles cases have been reported in 31 states, with active outbreaks in upstate New York and El Paso, Texas. New York has just declared the end of its yearlong outbreak, which required a massive public health response to control. Minnesota had a major measles outb...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Infectious diseases Prevention Travel health Source Type: blogs
Discussion Transplantation is not a common problem for primary care physicians but when a child’s disease has progressed to end-stage organ failure, transplantation can be the only treatment available. While the primary care provider usually is not involved in the daily management of patients before, during and after transplantation, they can be involved in many areas. These can include providing appropriate primary and acute care, ordering and obtaining necessary medical tests, medications and equipment, assisting with medical insurance, providing medical history and records to consultants, translating medical infor...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Readers in some of the 22 states where measles have been diagnosed this year discuss how the fear of catching the disease is affecting their daily lives.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Measles Epidemics Vaccination and Immunization Disabilities Source Type: news
A young boy in Pakistan receives an oral polio vaccine (OPV). Over the last 30 years huge progress has been made against polio and it is now only endemic in 2 countries, Afghanistan and Pakistan, with only 33 cases confirmed cases last year. Credit: Ashfaq Yusufzai/IPSBy Tharanga YakupitiyageUNITED NATIONS, May 1 2019 (IPS) Since the introduction of vaccines, diseases such as measles and polio were quickly becoming a thing of the past. However, the world’s progress on immunisation is now being threatened. According to the World Health Organisation (WHO), 85 percent of the world’s children received basic va...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Featured Global Headlines Health IPS UN: Inside the Glasshouse North America Population Regional Categories TerraViva United Nations diptheria-tetanus-pertussis (DTP) human papillomavirus (HPV) Measles Vaccines World Health Organ Source Type: news
April is Autism Awareness Month. To review: Autism is one of the five pervasive developmental disorders (PDD) listed in the DSM 5 (Diagnostic and Statistical Manual) which provides diagnostic guidelines for mental health professionals. Autism is characterized by difficulties in social interactions, a narrow and particular range of interests and repetitive behaviors. Although it is thought to be caused by a combination of genetic and environmental factors, research has yet to identify the differences in the brain that determine what makes people with autism different from the norm. Since the combination of attributes can b...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aspergers Autism Communication anti-vaccination Asperger Syndrome Autism Awareness Month Autism Spectrum Disability polio Stereotypes Stigma Source Type: blogs
Conclusions Apart West Nile virus (78), thousands of congenital microcephaly cases, fetal brain tissue damage and neurological syndromes have been associated with ZIKV infection. Unfortunately, the epidemics of this mosquito born, and a relative stable virus is on a rise. Although congenital microcephaly is a rare disorder however, due to lack of standardized diagnostic test facilities, the incidence in the geographically widespread ZIKV epidemic regions is higher. Animals studies showed that ZIKV is a neurotropic virus. It directly targets the developing embryonic brain cells by inducing apoptosis, cell-cycle arrest, and...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Abstract BACKGROUND: Since special efforts are necessary to vaccinate people living far from fixed vaccination posts, decision makers are interested in knowing the economic value of such efforts. METHODS: Using our immunization geospatial information system platform and a measles compartment model, we quantified the health and economic value of a 2-dose measles immunization outreach strategy for children
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Conclusion: The incidence rate of non-communicable diseases increased over the decade and was associated with increased mortality and disability, reduced quality of life, and increased health-care costs, indicating an urgent need to establish prevention and control programs. The rising trend in the incidence of cancers may also become a health care issue in Saudi Arabia in the coming years. PMID: 30834424 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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