Obesity, diabetes and the risk of colorectal adenoma and cancer

Colorectal cancer (CRC) is the fourth most commonly diagnosed gastrointestinal (GI) malignancy and the third leading cause of cancer-related death worldwide. In the current case-control study, an association b...
Source: BMC Endocrine Disorders - Category: Endocrinology Authors: Tags: Research article Source Type: research

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Authors: Lega IC, Lipscombe LL Abstract Obesity and diabetes have both been associated with an increased risk of cancer. In the face of increasing obesity and diabetes rates worldwide, this is a worrying trend for cancer rates. Factors such as hyperinsulinemia, chronic inflammation, anti-hyperglycemic medications and shared risk factors have all been identified as potential mechanisms underlying the relationship. The most common obesity- and diabetes-related cancers are endometrial, colorectal and post menopausal breast cancers. In this review, we summarize the existing evidence that describes the complex relations...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
AbstractPurpose of ReviewTo discuss the controversy over the effect of dietary fiber (DF) on (1) outcomes in critical illness, (2) microbiome and metabolic homeostasis, and (3) current evidence and guidelines regarding supplementation in critically ill patients.Recent FindingsIn healthy individuals, consumption of DF is widely known as a long-term protecting factor against colon cancer, cardiovascular disease, and other metabolic disorders like obesity, type 2 diabetes, and fatty liver disease; in hospitalized patients, DF may have a beneficial effect in the incidence of diarrhea, infections, and length of stay. But, what ...
Source: Current Nutrition Reports - Category: Nutrition Source Type: research
Suppressive effects of the sodium‑glucose cotransporter 2 inhibitor tofogliflozin on colorectal tumorigenesis in diabetic and obese mice. Oncol Rep. 2019 Oct 07;: Authors: Kato J, Shirakami Y, Ohnishi M, Mizutani T, Kubota M, Sakai H, Ibuka T, Tanaka T, Shimizu M Abstract Sodium‑glucose cotransporter 2 inhibitors were developed for the treatment of diabetes mellitus. Although recent studies have indicated that sodium‑glucose cotransporter 2 inhibitors have suppressive effects on several types of cancer, their effects against colorectal cancer remain unknown. The purpose of the present study was t...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
WEDNESDAY, Oct. 23, 2019 -- Rising rates of obesity and diabetes could be pushing up rates of pancreatic cancer across the globe, a new report suggests. Global rates of colon cancer are also on the rise, although fewer cases are now proving deadly,...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Krishnankutty Colorectal cancer (CRC) is a leading killer cancer worldwide and one of the most common malignancies with increasing incidences of mortality. Guggulsterone (GS) is a plant sterol used for treatment of various ailments such as obesity, hyperlipidemia, diabetes, and arthritis. In the current study, anti-cancer effects of GS in human colorectal cancer cell line HCT 116 was tested, potential targets identified using mass spectrometry-based label-free shotgun proteomics approach and key pathways validated by proteome profiler antibody arrays. Comprehensive proteomic profiling identified 14 proteins as signi...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Conclusions: The MAHCP utilization rate in both the genders, particularly in men, was lower than it had been expected.Keywords: Cancer, diabetes mellitus, dyslipidemia, hypertension, screening
Source: International Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
DiscussionPatients reoperated for wound dehiscence face a significantly higher postoperative mortality than those without. Risk factors include male gender, age>  70 years, obesity, history of chronic obstructive pulmonary disease, and history of generalised inflammatory disease. Patients at high risk for developing wound dehiscence may, if identified preoperatively, benefit from active prevention measures implemented in routine surgical practice.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
Publication date: Available online 5 September 2019Source: Trends in Food Science &TechnologyAuthor(s): David de Paulo Farias, Fábio Fernandes de Araújo, Iramaia Angélica Neri-Numa, Glaucia Maria PastoreAbstractBackgroundCurrently, there is a growing interest in the identification of new molecules that promote health and exhibit potential for technological applications. Prebiotics are functional ingredients naturally occurring in some plant and animal foods that have received considerable attention from the pharmaceutical and food industries due to their positive health effects. With an increasing ...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
In conclusion, FQ and TFQ derivatives may unveil new antiobesity and anticancer agents in the future. Our research qualifies FQs and TFQs as promising candidates for the development of related α-dicarbonyl scavengers as therapeutic agents to protect cells against carbonyl stress. PMID: 31450926 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
Staying healthy is best done with expert help. We all need medical care at some point. And if chronic illness strikes, it requires the guidance of someone with the ability to make diagnoses and balance treatments that are often aimed at different organ systems. Primary care physicians (PCPs) are generalists who see adult patients for common ailments including respiratory infections, headaches, back pain, and urinary infections. They also manage chronic conditions such as high blood pressure, diabetes, heart disease, obesity, anxiety, and depression. In addition, PCPs have expertise in managing multiple treatments, medicati...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Source Type: blogs
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