Analysis of respiratory mechanics in animal models: Its use in understanding lung behavior in emphysema and asthma

Publication date: Available online 29 October 2019Source: Drug Discovery Today: Disease ModelsAuthor(s): Paolo José Cesare Biselli, Julia Benini Kohler, Renato Righetti, Iolanda de Fátima Lopes Calvo Tibério, Mílton de Arruda Martins, Fernanda Degobbi Tenorio Quirino dos Santos LopesRespiratory mechanics assessment in animal models of respiratory diseases is considered a reliable tool to understand how structural changes impact lung function. Mathematical models, such as the equation of motion and the constant-phase model are used to describe the properties of the respiratory system. The equation of motion is valued because it is relatively simple to apply and describes the respiratory systems with few parameters. The constant-phase model is more complex but provides more detailed information about different lung compartments. In this review, we summarize how respiratory mechanics have been used to describe lung behavior as well as how these measurements reflect the progression of structural changes caused by emphysema and asthma in animal models.
Source: Drug Discovery Today: Disease Models - Category: Drugs & Pharmacology Source Type: research