Nails in the coffin of fresh frozen plasma to prevent or treat bleeding in cirrhosis?

Patients with chronic liver disease (CLD) have complex changes in their haemostatic system. These changes often include thrombocytopenia, low levels of coagulation factors and inhibitors, low levels of fibrinolytic proteins and elevated levels of endothelium-derived haemostatic proteins, including the platelet adhesive molecule von Willebrand factor. Patients often have prolongation of conventional coagulation tests (prothrombin time and associated international normalised ratio (PT/INR) and activated partial thromboplastin time [aPTT]), interpreted as indicating an increased risk of bleeding complications, particularly from planned invasive procedures.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Editorial Source Type: research