Title: Comparative Effects of Di(n-Butyl) Phthalate Exposure on Fetal Germ Cell Development in the Rat and in Human Fetal Testis Xenografts

Conclusions: Our findings provide the first comparison of DBP effects in vivo on germ cell number, differentiation and aggregation in human and rat. They show comparable effects on germ cells in both species, but the effects in the human were muted compared with the rat. Nevertheless, phthalate effects on germ cells have potential implications for the next generation, which merits further study. Our results show that the rat is a human-relevant model in which to explore the mechanisms for germ cell effects.
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Article Source Type: research