Targeting PKC ι-PAK1 signaling pathways in EGFR and KRAS mutant adenocarcinoma and lung squamous cell carcinoma

p21-activated kinase 1 (PAK1) stimulates growth and metastasis in non-small cell lung cancer (NSCLC). Protein kinase C iota (PKC ι) is an enzyme highly expressed in NSCLC, regulating PAK1 signaling. In the pres...

Source: Cell Communication and Signaling - October 28, 2019 Category: Molecular Biology Authors: Masaoki Ito, Carles Codony-Servat, Jordi Codony-Servat, David Llig é, Imane Chaib, Xiaoyan Sun, Jing Miao, Rongwei Sun, Xueting Cai, Alberto Verlicchi, Morihito Okada, Miguel Angel Molina-Vila, Niki Karachaliou, Peng Cao and Rafael Rosell Tags: Research Source Type: research