Laparoscopic Sleeve Gastrectomy or Laparoscopic Gastric Bypass for Patients with Metabolic Syndrome: An MBSAQIP Analysis.
Laparoscopic Sleeve Gastrectomy or Laparoscopic Gastric Bypass for Patients with Metabolic Syndrome: An MBSAQIP Analysis. Am Surg. 2019 Oct 01;85(10):1108-1112 Authors: Alizadeh RF, Li S, Gambhir S, Hinojosa MW, Smith BR, Stamos MJ, Nguyen NT Abstract In patients undergoing bariatric surgery, the presence of metabolic syndrome (MetS) contributes to perioperative morbidity. We aimed to evaluate the utilization and outcome of severely obese patients with MetS who underwent laparoscopic sleeve gastrectomy (LSG) versus laparoscopic Roux-en-Y gastric bypass (LRYGB). Using the 2015 and 2016 Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program database, data were obtained for patients with MetS undergoing LSG or LRYGB. There were 29,588 MetS patients (LSG: 58.7% vs LRYGB: 41.3%). There was no significant difference in 30-day mortality (0.1% for LSG vs 0.2% for LRYGB, adjusted odds ratio (AOR) 0.58, confidence interval (CI) 0.32-1.05, P = 0.07) or length of stay between groups (2 ± 2 for LSG vs 2.2 ± 2 days for LRYGB, P = 0.40). Compared with LRYGB, LSG was associated with significantly shorter operative time (78 ± 39 vs 122 ± 54 minutes, P
Conditions: Metabolic Syndrome; Overweight or Obesity; PreDiabetes; Weight Loss; Quality of Life Intervention: Behavioral: Time-Restricted Eating Sponsors: Nicolaus Copernicus University; Salk Institute for Biological Studies; University of California, San Diego; Center for Obesity and Metabolic Disorders Treatment Bydgoszcz Recruiting
AbstractDe ‐glucosylation and re‐glucosylation of glycoproteins by glucosidase II and uridine diphosphate‐glucose: glycoprotein glucosyltransferase 1 (UGGT1), respectively, are important steps in glycoprotein quality control. Misfolded glycoprotein accumulation is associated with endoplasmic reticulum st ress and can lead to protein misfolding diseases such as metabolic syndrome. Here, we analyzed the expression and activities of glucosidase II and UGGT1 in rat models of obesity and obese type 2 diabetes, phenotypes associated with moderate and severe metabolic syndrome, respectively. In obesity, th e mRNA and protei...