What is the role of the microenvironment in MDS?

Publication date: Available online 28 October 2019Source: Best Practice & Research Clinical HaematologyAuthor(s): Laura M. Calvi, Allison J. Li, Michael W. BeckerAbstractTreating myelodysplastic syndromes (MDS) can be complex. Hematopoiesis occurs within a heterogeneous and complex dynamic microenvironment, and a multiplicity of mutations in hematopoietic stem and progenitor cells (HSPCs) lead to MDS. But is there a role for the microenvironment? Here we review experimental and conceptual arguments that support a role for the microenvironment, provide evidence for the disruption of the microenvironment in MDS, and explore microenvironmental signals that may provide a targetable and conserved vulnerability in MDS that transcend genetic heterogeneity.
Source: Best Practice and Research Clinical Haematology - Category: Hematology Source Type: research