Advancing Sepsis Research: New Models and Novel Approaches

At the September meeting of the NIGMS Advisory Council, I delivered the Institute’s response to the recommendations of the Working Group on Sepsis. For more information, you can watch the videocast of the presentation.

Watch the sepsis presentation at the September Advisory Council meeting.

As a funding institute, we want
to rebalance our research portfolio to
invest in sepsis in more targeted, strategic ways. Planned efforts include:

Placing greater emphasis on patient-derived materials (“bedside to bench”)Developing a mechanistic understanding in patients to categorize sepsis endotypesPromoting discovery science as a foundation for future clinical studiesEncouraging new approaches for sepsis research, including:Computational and data sciencesNovel research organisms as models for humansTechnology development programsDe-emphasizing support in some areas, including:Use of rodent models, except where uniquely well justifiedLarge-scale clinical trials, in order to prioritize fundamental basic research

Accordingly, we have published two NIH Guide notices:

Notice of Information: NIGMS Priorities for Sepsis Research (NOT-GM-19-054)Request for Information (RFI): Strategies to Support Acquisition and Use of Biospecimens for Research on Sepsis in Humans (NOT-GM-19-057) (Responses are due by November 15, 2019)

NIGMS especially wants to stimulate interest in sepsis
research by investigators who may not have been aware of the challenges of
identifyin...

Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - October 28, 2019 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Research Administration NIGMS Advisory Council Sepsis Research Source Type: blogs