Molecules, Vol. 24, Pages 3886: Recent Advances in the Discovery of Novel Antiprotozoal Agents

Molecules, Vol. 24, Pages 3886: Recent Advances in the Discovery of Novel Antiprotozoal Agents Molecules doi: 10.3390/molecules24213886 Authors: Lee Kim Hayat Shin Parasitic diseases have serious health, social, and economic impacts, especially in the tropical regions of the world. Diseases caused by protozoan parasites are responsible for considerable mortality and morbidity, affecting more than 500 million people worldwide. Globally, the burden of protozoan diseases is increasing and is been exacerbated because of a lack of effective medication due to the drug resistance and toxicity of current antiprotozoal agents. These limitations have prompted many researchers to search for new drugs against protozoan parasites. In this review, we have compiled the latest information (2012–2017) on the structures and pharmacological activities of newly developed organic compounds against five major protozoan diseases, giardiasis, leishmaniasis, malaria, trichomoniasis, and trypanosomiasis, with the aim of showing recent advances in the discovery of new antiprotozoal drugs.
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research